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Titolo:
Anxiolytic-like effects of 7-nitroindazole in the rat plus-maze test
Autore:
Yildiz, F; Ulak, G; Erden, BF; Gacar, N;
Indirizzi:
Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Derince, Kocaeli, Turkey Kocaeli Univ Derince Kocaeli Turkey TR-41900 900 Derince, Kocaeli, Turkey
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 65, anno: 2000,
pagine: 199 - 202
SICI:
0091-3057(200002)65:2<199:AEO7IT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; NMDA RECEPTOR ANTAGONISTS; 7-NITRO INDAZOLE; NERVOUS-SYSTEM; ANXIETY; NEUROTRANSMITTER; INHIBITION; AGONISTS; MODEL;
Keywords:
anxiety; plus-maze test; nitric oxide; 7-nitroindazole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Yildiz, F Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Derince, Kocaeli, Turkey Kocaeli Univ Derince Kocaeli Turkey TR-41900 e, Kocaeli, Turkey
Citazione:
F. Yildiz et al., "Anxiolytic-like effects of 7-nitroindazole in the rat plus-maze test", PHARM BIO B, 65(2), 2000, pp. 199-202

Abstract

It is considered that nitric oxide (NO) is one of the most interesting research subjects. Because the actual role of NO in the mechanism of anxiety is still unclear, in this study, the involvement of NO in the mechanism of anxiety was investigated, using the plus-maze test. 7-Nitroindazole (7-NI) (15, 30, 60, 90, and 120 mg/kg), a new nitric oxide synthase (NOS) inhibitorwas studied. The time spent on open arms and open-arm visits was evaluated. 7-NI, at 15-120 mg/kg doses potently increased the time spent on open arms and open-arm visits. However, at 120 mg/kg it attenuated the time spent on the open arms, compared to at 90 mg/kg. This effect was attributed to decreased locomotor activity in the higher dose group. Neither L-arginine, norD-arginine (100 mg/kg) significantly affected any of the behavioral parameters measured in the rat elevated plus-maze test. Neither drugs revealed any effect on locomotion. L-Arginine but not D-arginine given 10 min before 7-NI, reversed the 7-NI induced anxiolytic-like effects. These data support an involvement of NO in the process of anxiety, and further suggest that the anxiolytic-like effect of 7-NI may be attributable to the inhibition of NO synthesis. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:33:58