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Titolo:
Prognostic significance of p27(kip1) protein expression and spontaneous apoptosis in patients with colorectal adenocarcinomas
Autore:
Tenjo, T; Toyoda, M; Okuda, J; Watanabe, I; Yamamoto, T; Tanaka, K; Ohtani, M; Nohara, T; Kawasaki, H; Tanigawa, N;
Indirizzi:
Osaka Med Coll, Dept Gen & Gastroenterol Surg, Takatsuki, Osaka 5698686, Japan Osaka Med Coll Takatsuki Osaka Japan 5698686 atsuki, Osaka 5698686, Japan
Titolo Testata:
ONCOLOGY
fascicolo: 1, volume: 58, anno: 2000,
pagine: 45 - 51
SICI:
0030-2414(2000)58:1<45:PSOPPE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT KINASE INHIBITOR; BREAST-CANCER; GASTRIC-CARCINOMA; PROSTATE-CANCER; P27 EXPRESSION; CYCLIN D1; CELL; METASTASIS; RESISTANCE; PARAMETERS;
Keywords:
p27(kip1) expression; apoptosis; prognosis; colorectal adenocarcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tanigawa, N Osaka Med Coll, Dept Gen & Gastroenterol Surg, 2-7 Daigakumachi, Takatsuki, Osaka 5698686, Japan Osaka Med Coll 2-7 Daigakumachi Takatsuki Osaka Japan 5698686
Citazione:
T. Tenjo et al., "Prognostic significance of p27(kip1) protein expression and spontaneous apoptosis in patients with colorectal adenocarcinomas", ONCOL-BASEL, 58(1), 2000, pp. 45-51

Abstract

Tumor cell apoptosis, proliferation and p27 expression using an in situ apoptosis detection kit, anti-Ki67 antibody and anti-p27 antibody were investigated in 171 colorectal adenocarcinoma specimens, together with the assessment of mutated p53 expression. No apparent association was observed among p27 expression, mutated p53 accumulation, the Ki67 labeling index and the apoptotic index (AI). In the multivariate analysis using the median values as the cut-off points (46.8% for p27 expression and 0.89% for AI), p27 expression was identified as an independent and significant predictor for overall survival. When the present series of patients were dichotomized by these cut-off points to categorize the cases into 4 subgroups, the patients in the group with low p27 expression and a low AI had the poorest prognosis. Theassessment of p27 expression and AI therefore may prove valuable in identifying patients with colorectal adenocarcinoma who may have a poor prognosis. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:41:54