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Titolo:
The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells
Autore:
Nikolopoulos, SN; Spengler, BA; Kisselbach, K; Evans, AE; Biedler, JL; Ross, RA;
Indirizzi:
Fordham Univ, Dept Biol Sci, Neurobiol Lab, Bronx, NY 10458 USA Fordham Univ Bronx NY USA 10458 l Sci, Neurobiol Lab, Bronx, NY 10458 USA Childrens Hosp Philadelphia, Div Oncol, Abramson Pediat Res Ctr, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA
Titolo Testata:
ONCOGENE
fascicolo: 3, volume: 19, anno: 2000,
pagine: 380 - 386
SICI:
0950-9232(20000120)19:3<380:THNAPE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURO-BLASTOMA CELLS; RAS-TRANSFORMED FIBROBLASTS; SIGNALING PATHWAYS; CYTOPLASMIC DOMAIN; BETA-CATENIN; EXPRESSION; ADHESION; CDNA; CYTOSKELETAL; GROWTH;
Keywords:
alpha-actinin; chromosome #4; tumor suppression; human neuroblastoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Ross, RA Fordham Univ, Dept Biol Sci, Neurobiol Lab, 441 E Fordham Road, Bronx, NY 10458 USA Fordham Univ 441 E Fordham Road Bronx NY USA 10458 , NY 10458 USA
Citazione:
S.N. Nikolopoulos et al., "The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells", ONCOGENE, 19(3), 2000, pp. 380-386

Abstract

alpha-Actinins are actin-binding proteins important in organization of thecytoskeleton and in cell adhesion. We have cloned and characterized a cDNAfrom human neuroblastoma cell variants which encodes the second non-musclealpha-actinin isoform designated ACTN4 (actinin-4), mRNA encoded by the ACTN4 gene, mapped to chromosome 4, is abundant in non-tumorigenic, substrate-adherent human neuroblastoma cell variants but absent or only weakly expressed in malignant, poorly substrate-adherent neuroblasts, It is also present in many adherent tumor cell lines of diverse tissue origins. Cell lines typically co-express ACTN4 and ACTN1, a second non-muscle alpha-actinin gene. Expression is correlated with substrate adhesivity, Analysis of deduced amino acid sequences suggests that the two isoforms may differ in function and in regulation by calcium. Moreover, ACTN4 exhibits tumor suppressor activity. Stable clones containing increased levels of alpha-actinin, isolated from highly malignant neuroblastoma stem cells [BE(2)-C] after transfectionwith a full-length ACTN4 cDNA, show decreased anchorage-independent growthability, loss of tumorigenicity in nude mice, and decreased expression of the N-myc proto-oncogene.

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Documento generato il 05/12/20 alle ore 13:52:33