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Titolo:
HGBASE: a database of SNPs and other variations in and around human genes
Autore:
Brookes, AJ; Lehvaslaiho, H; Siegfried, M; Boehm, JG; Yuan, YP; Sarkar, CM; Bork, P; Ortigao, F;
Indirizzi:
Karolinska Inst, Ctr Genome Res, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Res, S-17177 Stockholm, Sweden European Bioinformat Inst, Hinxton CB10 1SD, Cambs, England European Bioinformat Inst Hinxton Cambs England CB10 1SD , Cambs, England Interact Biotechnol GmbH, D-89077 Ulm, Germany Interact Biotechnol GmbH Ulm Germany D-89077 GmbH, D-89077 Ulm, Germany European Mol Biol Lab, D-69117 Heidelberg, Germany European Mol Biol Lab Heidelberg Germany D-69117 117 Heidelberg, Germany
Titolo Testata:
NUCLEIC ACIDS RESEARCH
fascicolo: 1, volume: 28, anno: 2000,
pagine: 356 - 360
SICI:
0305-1048(20000101)28:1<356:HADOSA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Brookes, AJ Karolinska Inst, Ctr Genome Res, Theorells Vag 3, S-17177 Stockholm, Sweden Karolinska Inst Theorells Vag 3 Stockholm Sweden S-17177 eden
Citazione:
A.J. Brookes et al., "HGBASE: a database of SNPs and other variations in and around human genes", NUCL ACID R, 28(1), 2000, pp. 356-360

Abstract

Human genome polymorphism is expected to play a key role in defining the etiologic basis of phenotypic differences between individuals in aspects such as drug responses and common disease predisposition, Relevant functional DNA changes will probably be located in or near to transcribed sequences, and include many single nucleotide polymorphisms. To aid the future analysisof such genome variation, HGBASE (Human Genic Bi-Allelic SEquences) was constructed as a means to gather human gene-linked polymorphisms from all possible public sources, and show these as a non-redundant set of records in astandardized and user-friendly database endowed with text and sequence based search facilities, After 1 year of presence on the WWW, the HGBASE project has compiled data for over 22 000 records, and this number continues to triple every 6-12 months with data harvested or submitted from all major public genome databases and published literature from the previous decade. Extensive annotation enhancement, internal consistency checking and manual review of every record is undertaken to address potential errors and deficiencies sometimes present in the original source data. The fully polished and comprehensive database is made freely available to all at http://hgbase.cgr.ki.se.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:01:11