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Titolo:
Effects of methoxyflurane anesthesia on the pharmacokinetics of I-125-IAZAin Sprague-Dawley rats
Autore:
Stypinski, D; Wiebe, LI; Tam, YK; Mercer, JR; McEwan, AJB;
Indirizzi:
Univ Alberta, Noujaim Inst Pharmaceut Oncol Res, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada Univ Alberta Edmonton AB Canada T6G 2N8 Sci, Edmonton, AB T6G 2N8, Canada Univ Alberta, Dept Radiol & Diagnost Imaging, Edmonton, AB T6G 2M7, CanadaUniv Alberta Edmonton AB Canada T6G 2M7 ing, Edmonton, AB T6G 2M7, Canada Cross Canc Inst, Edmonton, AB T6G 1Z2, Canada Cross Canc Inst Edmonton ABCanada T6G 1Z2 , Edmonton, AB T6G 1Z2, Canada
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 8, volume: 26, anno: 1999,
pagine: 959 - 965
SICI:
0969-8051(199911)26:8<959:EOMAOT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMAGING AGENT; TUMOR HYPOXIA; LIVER; FLUOROMISONIDAZOLE; ARABINOSIDE; ISCHEMIA; TISSUE; ETHER;
Keywords:
hypoxia; pharmacokinetics; IAZA; radiopharmaceuticals; anesthesia; methoxyflurane;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Wiebe, LI Univ Alberta, Noujaim Inst Pharmaceut Oncol Res, Fac Pharm & Pharmaceut Sci, 3118 Dent Pharm Ctr, Edmonton, AB T6G 2N8, Canada Univ Alberta3118 Dent Pharm Ctr Edmonton AB Canada T6G 2N8 nada
Citazione:
D. Stypinski et al., "Effects of methoxyflurane anesthesia on the pharmacokinetics of I-125-IAZAin Sprague-Dawley rats", NUCL MED BI, 26(8), 1999, pp. 959-965

Abstract

Effects of methoxyflurane anesthesia on the pharmacokinetics of intravenous I-125-IAZA in rats are reported. No significant differences in t(1/2 alpha), t(1/2 beta), V-ss, and Cl-TB for total radioactivity (I-125-IAZA and metabolites) were observed between the anesthetized (Group 1, n = 4) and nonanesthetized (Group 2, n = 3) animals. For I-125-IAZA, Cl-TB increased from 646 +/- 52 ml/h/kg to 2250 +/- 351 ml/h/kg and t(1/2 beta) decreased from 97.7 +/- 17.5 min to 35.6 +/- 5.4 min, for Groups 1 and 2, respectively. There were no differences in V-ss or t(1/2 alpha) between the two groups. These findings support literature reports of anesthetic effects on xenobiotic pharmacokinetics, and indicate a need for caution in the evaluation of preclinical imaging studies in which animals are immobilized with anesthetics. (C) 2000 Elsevier Science Inc. All rights reserved.

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Documento generato il 26/01/20 alle ore 01:08:56