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Titolo:
The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children.
Autore:
Neuzil, KM; Mellen, BG; Wright, PF; Mitchel, EF; Griffin, MR;
Indirizzi:
Dept Vet Affairs, Puget Sound Hlth Care Syst, Div Infect Dis 111, Seattle,WA 98108 USA Dept Vet Affairs Seattle WA USA 98108 nfect Dis 111, Seattle,WA 98108 USA Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA Univ WashingtonSeattle WA USA 98195 Med, Dept Med, Seattle, WA 98195 USA Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 event Med, Nashville, TN 37212 USA Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 pt Pediat, Nashville, TN 37212 USA Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Dept Med, Nashville, TN 37212 USA
Titolo Testata:
NEW ENGLAND JOURNAL OF MEDICINE
fascicolo: 4, volume: 342, anno: 2000,
pagine: 225 - 231
SICI:
0028-4793(20000127)342:4<225:TEOIOH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNCYTIAL VIRUS-INFECTION; RESPIRATORY-DISEASE; YOUNG-CHILDREN; OTITIS-MEDIA; A-VIRUS; IMPACT; VACCINE; EPIDEMIOLOGY; MORTALITY; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Neuzil, KM Dept Vet Affairs, Puget Sound Hlth Care Syst, Div Infect Dis 111, 1660 S Columbian Way, Seattle, WA 98108 USA Dept Vet Affairs 1660 S Columbian Way Seattle WA USA 98108 USA
Citazione:
K.M. Neuzil et al., "The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children.", N ENG J MED, 342(4), 2000, pp. 225-231

Abstract

Background: Despite high annual rates of influenza in children, influenza vaccines are given to children infrequently. We measured the disease burdenof influenza in a large cohort of healthy children in the Tennessee Medicaid program who were younger than 15 years of age. Methods: We determined the rates of hospitalization for acute cardiopulmonary conditions, outpatient visits, and courses of antibiotics over a periodof 19 consecutive years. Using the differences in the rates of these events when influenzavirus was circulating and the rates from November through April when there was no influenza in the community, we calculated morbidity attributable to influenza. There was a total of 2,035,143 person-years of observation. Results: During periods when influenzavirus was circulating, the average number of hospitalizations for cardiopulmonary conditions in excess of the expected number was 104 per 10,000 children per year for children younger than 6 months of age, 50 per 10,000 per year for those 6 months to less than 12 months, 19 per 10,000 per year for those 1 year to less than 3 years, 9 per 10,000 per year for those 3 years to less than 5 years, and 4 per 10,000 per year for those 5 years to less than 15 years. For every 100 children,an annual average of 6 to 15 outpatient visits and 3 to 9 courses of antibiotics were attributable to influenza. In winter, 10 to 30 percent of the excess number of courses of antibiotics occurred during periods when influenzavirus was circulating. Conclusions: Healthy children younger than one year of age are hospitalized for illness attributable to influenza at rates similar to those for adults at high risk for influenza. The rate of hospitalization decreases markedly with age. Influenza accounts for a substantial number of outpatient visits and courses of antibiotics in children of all ages. (N Engl J Med 2000; 342:225-31. ) (C)2000, Massachusetts Medical Society.

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Documento generato il 05/04/20 alle ore 18:50:58