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Titolo:
Structure and function of dopamine receptors
Autore:
Vallone, D; Picetti, R; Borrelli, E;
Indirizzi:
Univ Strasbourg 1, CNRS, Inst Genet & Biol Mol & Cellulaire, INSERM, F-67404 Illkirch, France Univ Strasbourg 1 Illkirch France F-67404 SERM, F-67404 Illkirch, France
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 1, volume: 24, anno: 2000,
pagine: 125 - 132
SICI:
0149-7634(200001)24:1<125:SAFODR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; CONDITIONED PLACE PREFERENCE; IMMEDIATE-EARLY GENE; RAT STRIATUM; C-FOS; MOLECULAR-BIOLOGY; MICE LACKING; D2 RECEPTORS; D1 RECEPTOR; G-PROTEINS;
Keywords:
dopamine; dopamine receptors; knock-out mice; neuronal disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Borrelli, E Univ Strasbourg 1, CNRS, Inst Genet & Biol Mol & Cellulaire, INSERM, BP 163,CU Strasbourg, F-67404 Illkirch, France Univ Strasbourg 1 BP 163,CU Strasbourg Illkirch France F-67404
Citazione:
D. Vallone et al., "Structure and function of dopamine receptors", NEUROSCI B, 24(1), 2000, pp. 125-132

Abstract

Dopamine (DA) is the most abundant catecholamine in the brain. The involvement and importance of DA as a neurotransmitter in the regulation of different physiological functions in the central nervous system (CNS) is well known. Deregulation of the dopaminergic system has been linked with Parkinson's disease, Tourette's syndrome, schizophrenia, attention deficit hyperactive disorder (ADHD) and generation of pituitary tumours. This review focuses on the pharmacological and biochemical features shared by the dopamine receptors. We address their coupling to secondary messenger pathways and their physiological function based upon studies using pharmacological tools, specific brain lesions and, more recently, genetically modified animal models. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:17:14