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Titolo:
Epigenetic cues in midbrain dopaminergic neuron development
Autore:
Perrone-Capano, C; Da Pozzo, P; di Porzio, U;
Indirizzi:
CNR, Ist Int Genet & Biofis, I-80125 Naples, Italy CNR Naples Italy I-80125 , Ist Int Genet & Biofis, I-80125 Naples, Italy Univ Catanzaro, Fac Farm, I-88021 Roccelletta Di Borgia, Italy Univ Catanzaro Roccelletta Di Borgia Italy I-88021 etta Di Borgia, Italy
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 1, volume: 24, anno: 2000,
pagine: 119 - 124
SICI:
0149-7634(200001)24:1<119:ECIMDN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPORTER GENE-EXPRESSION; STRIATAL TARGET-CELLS; TYROSINE-HYDROXYLASE; INVITRO MATURATION; MOUSE EMBRYOS; IN-VITRO; DISORDER; NURR1; MICE;
Keywords:
brain grafts; bFGF; DAT; high affinity dopamine uptake; mesencephalon; neuronal differentiation; Nurr1; primary cultures; RT-PCR; striatum; tyrosine hydroxylase; VMAT2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Perrone-Capano, C CNR, Ist Int Genet & Biofis, Via Marconi 10, I-80125 Naples, Italy CNR Via Marconi 10 Naples Italy I-80125 5 Naples, Italy
Citazione:
C. Perrone-Capano et al., "Epigenetic cues in midbrain dopaminergic neuron development", NEUROSCI B, 24(1), 2000, pp. 119-124

Abstract

Midbrain dopaminergic (DA) neurons subserve complex and varied neural functions in vertebrate CNS. Their progenitors give rise to DA neurons by the action of two extracellular inducers, Sonic Hedgehog and FGF8. After this first commitment, the function of selectively activated transcription factors, like the orphan steroid nuclear receptor Nurr1, is required for DA final determination Subsequently, DA function is selectively modulated by specific interaction with the developing striatal target tissue. Committed and determined DA neurons express the key genes involved in DA neurotransmission at different times in development. Synthesis and intracellular accumulation of DA is achieved shortly after expression of Nurr1, while high affinity uptake, responsible for ending the neurotransmission, takes place after a fewdays. Cell contacts between the presynaptic DA neurons and target striatalneurons are apparently necessary for the fine modulation of DA function, in vivo and in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:23:19