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Titolo:
Effect of acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline on muscle tone, metabolism of dopamine pn the striatum and tyrosine hydroxylase immunocytochemistry in the substantia nigra, in rats
Autore:
Lorenc-Koci, E; Smialowska, M; Antkiewicz-Michaluk, L; Golembiowska, K; Bajkowska, M; Wolfarth, S;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 eurobiol, PL-31343 Krakow, Poland Polish Acad Sci, Inst Pharmacol, Dept Biochem, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 Biochem, PL-31343 Krakow, Poland Polish Acad Sci, Inst Pharmacol, Dept Pharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 95, anno: 2000,
pagine: 1049 - 1059
SICI:
0306-4522(2000)95:4<1049:EOAACA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-METHYLISOQUINOLINIUM ION; IDIOPATHIC PARKINSONS-DISEASE; MONOAMINE-OXIDASE; ENDOGENOUS SUBSTANCE; INVIVO RELEASE; C57BL/6J MICE; HUMAN-BRAIN; TETRAHYDROISOQUINOLINE; RIGIDITY; N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE;
Keywords:
Parkinson's disease; muscle rigidity; endogenous toxins; 1,2,3,4-tetrahydroisoquinoline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Lorenc-Koci, E Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol,12 Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St KrakowPoland PL-31343 Poland
Citazione:
E. Lorenc-Koci et al., "Effect of acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline on muscle tone, metabolism of dopamine pn the striatum and tyrosine hydroxylase immunocytochemistry in the substantia nigra, in rats", NEUROSCIENC, 95(4), 2000, pp. 1049-1059

Abstract

The effects of acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline, an endogenous substance suspected of producing parkinsonism in humans, on the muscle tone and metabolism of dopamine in the striatum, and on the number of tyrosine hydroxylase-immunoreactive cells in the substantia nigra were investigated in rats. Muscle tone was examined using a combined mechanomyographic and electromyographic method which measured simultaneouslythe muscle resistance of the rat's hind foot to passive extension and flexion in the ankle joint and electromyographic activity of the antagonistic muscles of that joint: gastrocnemius and tibialis anterior. 1,2,3,4-Tetrahydroisoquinoline administered at doses of 50 and 100 mg/kg intraperitoneally for 19 days increased muscle resistance 1 h after the first injection (acute treatment), I h after the last injection (chronic treatment) and three days after compound withdrawal. Rigidity observed on the third day of 1,2,3,4-tetrahydroisoquinoline withdrawal was accompanied by an increased tonic (resting) electromyographic activity of the gastrocnemius and tibialis anterior muscles. At the same time, a significant reduction in the number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra and a decrease in the dopamine level in the striatum were also found. A declining number of tyrosine hydroxylase-immunoreactive neurons in the whole substantia nigra showed a significant negative correlation with the enhanced muscle resistance, as well as with the tonic electromyographic activity recorded at rest, i.e. before the start of movements, from the gastrocnemius and tibialis anterior muscles. Our results suggest that 1,2,3,4-tetrahydroisoquinoline may be one of the endogenous substances involved in the progress of Parkinson's disease. (C) 1999 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:35:53