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Titolo:
Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus
Autore:
Ehrenreich, H; Nau, R; Dembowski, C; Hasselblatt, M; Barth, M; Hahn, A; Schilling, L; Siren, AL; Bruck, W;
Indirizzi:
Max Planck Inst Expt Med, D-37075 Gottingen, Germany Max Planck Inst Expt Med Gottingen Germany D-37075 75 Gottingen, Germany Univ Gottingen, Dept Neurol, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 rol, D-37075 Gottingen, Germany Univ Gottingen, Dept Psychiat, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 iat, D-37075 Gottingen, Germany Univ Gottingen, Dept Neuropathol, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 hol, D-37075 Gottingen, Germany Univ Heidelberg Hosp, Dept Neurosurg, D-68135 Mannheim, Germany Univ Heidelberg Hosp Mannheim Germany D-68135 D-68135 Mannheim, Germany Knoll AG, Dept Cardiovasc Res, D-6700 Ludwigshafen, Germany Knoll AG Ludwigshafen Germany D-6700 c Res, D-6700 Ludwigshafen, Germany
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 95, anno: 2000,
pagine: 993 - 1001
SICI:
0306-4522(2000)95:4<993:EBRDIA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC BRAIN INJURY; DNA FRAGMENTATION; SURVIVAL FACTOR; COAT COLOR; CELL-DEATH; GROWTH; PATHOPHYSIOLOGY; HIPPOCAMPUS; ASTROCYTES; EXPRESSION;
Keywords:
endothelin; endothelin B receptors; apoptosis; proliferation; dentate gyms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ehrenreich, H Max Planck Inst Expt Med, Hermann Rein Str 3, D-37075 Gottingen, Germany Max Planck Inst Expt Med Hermann Rein Str 3 Gottingen GermanyD-37075
Citazione:
H. Ehrenreich et al., "Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus", NEUROSCIENC, 95(4), 2000, pp. 993-1001

Abstract

The dentate gyrus retains neuronal proliferative potential throughout life. Using immature endothelin B receptor deficient (sl/sl) rats, a rabbit model of pneumococcal meningitis and autopsy brains from humans who died from pneumococcal meningitis, we explored the role of endothelin B receptors in physiological and pathological neuronal apoptosis in the dentate gyrus. At postnatal days 3-4, the rate of apoptosis in the dentate gyrus was high in all rats, declining to low levels in wild-type rats (+/+) on days 14 and 22, but remaining high in both homozygous (sl/sl) and heterozygous (sl/+) endothelin B receptor-deficient rats. Increased apoptosis was not significantly compensated for by neuronal proliferation. Hippocampal neuronal cultures also exhibited genotype-dependent apoptosis with the highest rare in neurons from homozygous endothelin B receptor-deficient (sl/sl) rats. In rabbit and human pneumococcal meningitis, increased apoptosis in the dentate gyrus was associated with loss of neuronal endothelin B receptor immunoreactivity. In conclusion, endothelin B receptors appear to act as neuronal survival factors in the dentate gyrus in rodents and man, both during postnatal development and under pathological conditions. (C) 1999 IBRO, Published by Elsevier Science Ltd.

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Documento generato il 13/07/20 alle ore 20:16:50