Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Topiramate depresses carbachol-induced plateau potentials in subicular bursting cells
Autore:
Palmieri, C; Kawasaki, H; Avoli, M;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Inst, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Neurol, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 urol, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Physiol, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 siol, Montreal, PQ H3A 2B4, Canada Univ Milan, Osped San Paolo, Ctr Epilessia, I-20142 Milan, Italy Univ Milan Milan Italy I-20142 aolo, Ctr Epilessia, I-20142 Milan, Italy
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 11, anno: 2000,
pagine: 75 - 78
SICI:
0959-4965(20000117)11:1<75:TDCPPI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTORHINAL CORTEX; IN-VITRO; NEURONS; PILOCARPINE; ORGANIZATION; MECHANISMS; RESPONSES; SEIZURES; EPILEPSY; CURRENTS;
Keywords:
carbachol; muscarinic excitation; plateau potentials; subiculum; topiramate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Avoli, M McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 A 2B4, Canada
Citazione:
C. Palmieri et al., "Topiramate depresses carbachol-induced plateau potentials in subicular bursting cells", NEUROREPORT, 11(1), 2000, pp. 75-78

Abstract

Intracellular recordings were made in an in vitro slice preparation to establish whether the antiepileptic drug topiramate reduces the depolarizing plateau potentials (PPs) induced in the rat subiculum by intracellular pulses of depolarizing current, in the presence of the cholinergic agonist carbachol (CCh, 70-100 mu M). PPs lasted up to about 2s, and disappeared during application of the muscarinic receptor antagonist atropine. Topiramate (10-100 mu M, n = 22 neurons) decreased and eventually abolished in a dose-dependent manner these PPs, even when the function of excitatory amino acid andGABA(A) receptors was blocked. Hence, topiramate depresses muscarinic receptor-dependent PPs in the rat subiculum, thus suggesting that this form of excitation may represent a target for the mechanism of action of this antiepileptic compound. NeuroReport 11:75-78 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:30:38