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Titolo:
Role of dopamine D-3 receptors in thermoregulation: a reappraisal
Autore:
Perachon, S; Betancur, C; Pilon, C; Rostene, W; Schwartz, JC; Sokoloff, P;
Indirizzi:
Ctr Paul Broca, INSERM, U109, Unite Neurobiol & Pharmacol Mol, F-75014 Paris, France Ctr Paul Broca Paris France F-75014 Pharmacol Mol, F-75014 Paris, France Hop St Antoine, INSERM, U339, Unite Imagerie Cellulaire Neurorecepteurs & Physi, F-75571 Paris 12, France Hop St Antoine Paris France 12 epteurs & Physi, F-75571 Paris 12, France
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 11, anno: 2000,
pagine: 221 - 225
SICI:
0959-4965(20000117)11:1<221:RODDRI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT IN-VIVO; SELECTIVE ANTAGONIST; (+)-S-14297; ACTIVATION; MODULATION; NAFADOTRIDE; PATHWAYS; RELEASE; D3;
Keywords:
BP 897; D-2 receptor; D-3 receptor; hypothermia; knock-out mice; partial agonist; S 14297;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sokoloff, P Ctr Paul Broca, INSERM, U109, Unite Neurobiol & Pharmacol Mol,2ter Rue Alesia, F-75014 Paris, France Ctr Paul Broca 2ter Rue Alesia Paris France F-75014 s, France
Citazione:
S. Perachon et al., "Role of dopamine D-3 receptors in thermoregulation: a reappraisal", NEUROREPORT, 11(1), 2000, pp. 221-225

Abstract

Dopamine agonist-induced hypothermia has been proposed to be mediated by the D-3 receptor (D3R), as it is elicited by (+)7-OH-DPAT and antagonized byS 14297, two putative D3R-preferential ligands. Here we show, however, that S 14297 is a full and partial agonist at D3R and D2R, respectively. Hypothermia was induced in rats by agonists with potencies correlated with theirD3R and D2R functional potencies, and was reversed by antagonists, with a rank order of potency typical of the D2R. Moreover, BP 897, a highly potentand selective but partial D3R agonist was inactive in producing hypothermia or reversing (+)7-OH-DPAT-induced hypothermia. (+)7-OH-DPAT was as potentand efficient in inducing hypothermia in wild-type as in D3R-deficient mice. Hence, our results suggest that hypothermia does not result from a selective stimulation of the D3R. NeuroReport 11:221-225 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:53:14