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Titolo:
Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus
Autore:
Sergeyev, V; Broberger, C; Gorbatyuk, O; Hokfelt, T;
Indirizzi:
Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 11, anno: 2000,
pagine: 117 - 121
SICI:
0959-4965(20000117)11:1<117:EO2A2A>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANIN-CONCENTRATING HORMONE; AGOUTI OBESITY SYNDROME; NEUROPEPTIDE-Y; PARAVENTRICULAR NUCLEUS; FEEDING-BEHAVIOR; ARCUATE NUCLEUS; GENE-EXPRESSION; PROTEIN; RECEPTORS; APPETITE;
Keywords:
arcuate nucleus; antimetabolite; eating; food intake; hypothalamus; neuropeptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hokfelt, T Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 77 Stockholm, Sweden
Citazione:
V. Sergeyev et al., "Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus", NEUROREPORT, 11(1), 2000, pp. 117-121

Abstract

Using in situ hybridization, the mRNA levels encoding neuropeptide Y (NPY), agouti gene-related protein (AGRP), proopiomelanocortin (POMC), melanin-concentrating hormone (MCH) and hypocretin/orexin (HC/ORX) were investigatedin the rat arcuate nucleus (Arc) and lateral hypothalamic area (LHA) 2 h after a single dose of the glucose antimetabolite 2-deoxy-D-glucose (2-DG; 600 mg/kg) or of the fatty acid oxidation inhibitor mercaptoacetate (MA; 600mu mol/kg). Two hours after 2-DG or MA injection food intake was significantly increased. NPY and AGRP mRNA levels in the Are were increased by 2-DG but not affected by MA, and MCH mRNA levels in the LHA were increased by both antimetabolites. These results suggest that Are neurons expressing NPY and AGRP are regulated by changes in glucose, but not fatty acid availability, whereas both factors affect MCH neurons in the LHA. NeuroReport 11:117-121 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:04:12