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Titolo:
SNAP-25 is present on the Golgi apparatus of retinal neurons
Autore:
Morgans, C; Brandstatter, JH;
Indirizzi:
Max Planck Inst Hirnforsch, Abt Neuroanat, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 Frankfurt, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 11, anno: 2000,
pagine: 85 - 88
SICI:
0959-4965(20000117)11:1<85:SIPOTG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTOSOMAL-ASSOCIATED PROTEIN; CULTURED HIPPOCAMPAL-NEURONS; EVOKED DENDRITIC EXOCYTOSIS; INTEGRAL MEMBRANE-PROTEIN; SYNAPTIC VESICLES; SYNTAXIN; TRANSPORT; PALMITOYLATION; PHOTORECEPTOR; ORGANELLES;
Keywords:
Golgi; neurons; rat; retina; SNAP-25;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Morgans, C John Curtin Sch Med Res, Div Neurosci, Synapt Biochem Grp, Canberra, ACT 2600, Australia John Curtin Sch Med Res Canberra ACT Australia 2600 Australia
Citazione:
C. Morgans e J.H. Brandstatter, "SNAP-25 is present on the Golgi apparatus of retinal neurons", NEUROREPORT, 11(1), 2000, pp. 85-88

Abstract

SNAP-25 is a neuronal SNARE protein required for synaptic vesicle exocytosis and neurite outgrowth. Here we show that in addition to synaptic staining, SNAP-25 immunoreactivity is also localized to an intracellular, perinuclear compartment of retinal neurons. Double-labeling with an antibody against the 58 kD resident protein of the trans-golgi network Indicates that the intracellular SNAP-25 is localized to the Golgi complex. Immune-electron microscopic localization of SNAP-25 confirmed its presence on the Golgi apparatus of photoreceptors, bipolar cells, amacrine cells and ganglion cells inthe retina. These data implicate SNAP-25 in the trafficking of Golgi-derived vesicles in neurons in addition to the synaptic vesicle cycle. NeuroReport 11:85-88 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:21:16