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Titolo:
The nature and staging of attention dysfunction in early (minimal and mild) Alzheimer's disease: relationship to episodic and semantic memory impairment
Autore:
Perry, RJ; Watson, P; Hodges, JR;
Indirizzi:
Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, EnglandUniv Cambridge Cambridge England CB2 2QQ nit, Cambridge CB2 2QQ, England MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England MRC Cambridge England CB2 2EF Brain Sci Unit, Cambridge CB2 2EF, England
Titolo Testata:
NEUROPSYCHOLOGIA
fascicolo: 3, volume: 38, anno: 2000,
pagine: 252 - 271
SICI:
0028-3932(2000)38:3<252:TNASOA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CARD SORTING TEST; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBRAL GLUCOSE-METABOLISM; POSTERIOR CORTICAL ATROPHY; PLACEBO-CONTROLLED TRIAL; CINGULATE CORTEX; SUSTAINED ATTENTION; WORKING-MEMORY; DIVIDED ATTENTION;
Keywords:
Alzheimer's disease; attention; episodic memory; dementia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
126
Recensione:
Indirizzi per estratti:
Indirizzo: Hodges, JR Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ dge CB2 2QQ, England
Citazione:
R.J. Perry et al., "The nature and staging of attention dysfunction in early (minimal and mild) Alzheimer's disease: relationship to episodic and semantic memory impairment", NEUROPSYCHO, 38(3), 2000, pp. 252-271

Abstract

The development of cholinergic therapies for Alzheimer's disease (AD) has highlighted the importance of understanding the role of attentional deficits and the relationship between attention and memory in the earliest stages of the disease. Variability in the tasks used to examine aspects of attention, and in the disease severity, between studies makes it difficult to determine which aspects of attention are affected earliest in AD, and how attentional impairment is related to other cognitive modules. We tested 27 patients in the early stages of the disease on the basis of the MMSE (minimal 24-30 corresponding to minimal cognitive impairment, very mild or possible ADin other classifications; and mild 18-23) on a battery of attentional tests aimed to assess sustained, divided, and selective attention, plus tests of episodic memory, semantic memory, visuoperceptual and visuospatial function, and verbal short-term memory. Although the mildly demented group were impaired on all attentional tests, the minimally impaired group showed a preserved ability to sustain attention, and to divide attention based on a dual-task paradigm. The minimally demented group had particular problems with response inhibition and speed of attentional switching. Examination of the relationship between attention and other cognitive domains showed impaired episodic memory in all patients. Deficits in attention were more prevalent than deficits in semantic memory suggesting that they occur at an earlier stage and the two were partially independent. Impairment in visuoperceptual and visuospatial functions and verbal short-term memory were the least common. Although attention is impaired early in AD, 40% of our patients showed deficits in episodic memory alone, confirming that amnesia may be the only cognitive deficit in the earliest stages of sporadic AD. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:31:03