Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia
Autore:
Goldman-Wohl, DS; Ariel, I; Greenfield, C; Hochner-Celnikier, D; Cross, J; Fisher, S; Yagel, S;
Indirizzi:
Hadassah Univ Hosp, Dept Obstet & Gynecol, IL-91240 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91240 IL-91240 Jerusalem, Israel Hadassah Univ Hosp, Dept Pathol, IL-91240 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91240 IL-91240 Jerusalem, Israel Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada UCSF, Dept Stomatol, San Francisco, CA 94143 USA UCSF San Francisco CA USA 94143 ept Stomatol, San Francisco, CA 94143 USA
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 1, volume: 6, anno: 2000,
pagine: 88 - 95
SICI:
1360-9947(200001)6:1<88:LOHLAE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA-G EXPRESSION; G MESSENGER-RNA; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; PLACENTAL BED; NK CELLS; PREECLAMPSIA; IMPLANTATION; WOMEN; HYBRIDIZATION;
Keywords:
HLA-G; placenta; pre-eclampsia; spiral arteries; trophoblast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Yagel, S Hadassah Univ Hosp, Dept Obstet & Gynecol, IL-91240 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91240 Jerusalem, Israel
Citazione:
D.S. Goldman-Wohl et al., "Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia", MOL HUM REP, 6(1), 2000, pp. 88-95

Abstract

Pre-eclampsia, a common complication of first pregnancies, is thought to result from a poorly perfused placenta and may reflect an abnormal maternal immune reaction to the hemiallogenic fetus. Human leukocyte antigen (HLA)-G, a major histocompatibility tissue-specific antigen expressed in extravillous trophoblast cells (fetal-derived), may protect trophoblasts from maternal-fetal immune intolerance and allow these cells to invade the uterus. Through RNA in-situ hybridization analysis, we studied the expression pattern of HLA-G in normal placentae and placentae from pregnancies complicated by severe pre-eclampsia. In normal placenta we found HLA-G expression in the anchoring extravillous trophoblasts with an increasing gradient of expression in the more invasive cells. However, in nine out of 10 pre-eclamptic placentae HLA-G expression was absent or reduced. We conclude that HLA-G is normally expressed in invasive trophoblasts and HLA-G expression is defective in most pre-eclamptic placentae. We propose that trophoblasts lacking HLA-Gare vulnerable to attack by the maternal immune system. These defective trophoblasts will be unable to invade the maternal spiral arteries effectively, thereby developing vessels which cannot adequately nourish the developing placenta. This poorly perfused placenta may initiate the systemic cascadeof events associated with pre-eclampsia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:23:25