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Titolo:
Tie-2 and angiopoietin-2 expression at the fetal-maternal interface: a receptor ligand model for vascular remodelling
Autore:
Goldman-Wohl, DS; Ariel, I; Greenfield, C; Lavy, Y; Yagel, S;
Indirizzi:
Hadassah Univ Hosp, Dept Obstet & Gynecol, IL-91240 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91240 IL-91240 Jerusalem, Israel Hadassah Univ Hosp, Dept Pathol, IL-91240 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91240 IL-91240 Jerusalem, Israel
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 1, volume: 6, anno: 2000,
pagine: 81 - 87
SICI:
1360-9947(200001)6:1<81:TAAEAT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE; CYTOTROPHOBLAST DIFFERENTIATION; ENDOVASCULAR INVASION; ENDOTHELIAL-CELLS; MOLECULAR-CLONING; PLACENTAL BED; PRE-ECLAMPSIA; IMPLANTATION; PREECLAMPSIA; TEK;
Keywords:
angiopoietin-2; placenta; spiral artery; Tie-2; trophoblast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Yagel, S Hadassah Univ Hosp, Dept Obstet & Gynecol, POB 24035, IL-91240 Jerusalem, Israel Hadassah Univ Hosp POB 24035 Jerusalem Israel IL-91240 m, Israel
Citazione:
D.S. Goldman-Wohl et al., "Tie-2 and angiopoietin-2 expression at the fetal-maternal interface: a receptor ligand model for vascular remodelling", MOL HUM REP, 6(1), 2000, pp. 81-87

Abstract

The blood vessels at the fetal-maternal interface widen dramatically during pregnancy in order to increase blood flow to nourish the developing fetus. This vessel remodelling destroys normal vessel integrity and encompasses the dissolution of vessel muscle and elastic tissue. It also includes the displacement of endothelial cells by fetal trophoblasts that invade the maternal arteries of the uterus. Interaction between the endothelial cell receptor, Tie-a, and its recently discovered antagonist ligand, angiopoietin-2 (Ang-2), has been implicated in the loosening of vessel structure. Using Northern blot hybridization and RNA in-situ hybridization analysis the expression pattern of Tie-2, and Ang-2 in the placenta throughout pregnancy, was investigated. We found Ang-2 expressed in the syncytiotrophoblast during thefirst trimester. In addition to the expected expression of the Tie-2 receptor in both fetal and maternal endothelial cells, we observed Tie-2 expression in endovascular invasive trophoblasts. These cells of epithelial origininvade the uterine spiral arteries and acquire endothelial cell properties. The temporal- and lineage-specific pattern of expression of Tie-2 and Ang-2 suggests that this receptor-ligand pair functions during the critical phase of development of the fetal vasculature and reworking of the maternal vessels during normal placentation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:10:59