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Titolo:
Orphanin FQ/nociceptin inhibits morphine withdrawal
Autore:
Kotlinska, J; Suder, P; Legowska, A; Rolka, K; Silberring, J;
Indirizzi:
Jagiellonian Univ, Fac Chem, Neurobiochem Grp, PL-30060 Krakow, Poland Jagiellonian Univ Krakow Poland PL-30060 em Grp, PL-30060 Krakow, Poland Jagiellonian Univ, Reg Lab, PL-30060 Krakow, Poland Jagiellonian Univ Krakow Poland PL-30060 eg Lab, PL-30060 Krakow, Poland Med Acad, Dept Pharmacodynam, PL-20081 Lublin, Poland Med Acad Lublin Poland PL-20081 t Pharmacodynam, PL-20081 Lublin, Poland Univ Gdansk, Fac Chem, PL-80952 Gdansk, Poland Univ Gdansk Gdansk PolandPL-80952 sk, Fac Chem, PL-80952 Gdansk, Poland
Titolo Testata:
LIFE SCIENCES
fascicolo: 8, volume: 66, anno: 2000,
pagine: PL119 - PL123
SICI:
0024-3205(20000114)66:8<PL119:OFIMW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-OPIOID PEPTIDE; RECEPTOR; FQ; RAT; NEUROPEPTIDE; NOCICEPTIN; TOLERANCE; ANALGESIA; NEURONS; CLONING;
Keywords:
morphine dependence; morphine withdrawal; orphanin FQ/nociceptin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Silberring, J Jagiellonian Univ, Fac Chem, Neurobiochem Grp, Ingardena 3, PL-30060 Krakow, Poland Jagiellonian Univ Ingardena 3 Krakow Poland PL-30060 Poland
Citazione:
J. Kotlinska et al., "Orphanin FQ/nociceptin inhibits morphine withdrawal", LIFE SCI, 66(8), 2000, pp. PL119-PL123

Abstract

The influence of orphanin FQ/nociceptin (OFQ/N) on the morphine-withdrawalsymptom was investigated. Withdrawal syndrome was induced in the morphine-dependent rats by an intraperitoneal tip) injection of 2 mg/kg naloxone hydrochloride - an opioid receptors antagonist. Wet-dog shakes were used as a measure of the abstinence syndrome. Intraventricular injections of OFQ/N (5-20 mu g/animal) caused significant inhibition of the withdrawal signs at doses between 15-20 mu g, in the morphine-dependent rats. OFQ/N alone did not change behavior of the morphine-dependent animals. The obtained results indicate that OFQ/N can inhibit the morphine withdrawal symptoms induced by naloxone. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:41:44