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Titolo:
Dendritic cells in precancerous lesions of the larynx
Autore:
Sprinzl, GM; Hussl, B; Obrist, P; Yoneda, K; Thumfart, WF; Romani, N; Schrott-Fischer, A;
Indirizzi:
Innsbruck Univ, Dept Otorhinolaryngol Head & Neck Surg, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 Surg, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Pathol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 athol, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Dermatol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 matol, A-6020 Innsbruck, Austria Kyoto Univ, Dept Dermatol, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Dept Dermatol, Kyoto, Japan
Titolo Testata:
LARYNGOSCOPE
fascicolo: 1, volume: 110, anno: 2000,
pagine: 13 - 18
SICI:
0023-852X(200001)110:1<13:DCIPLO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LANGERHANS CELLS; METASTATIC MELANOMA; MALIGNANT-MELANOMA; CARCINOMA; ANTIGEN; TUMORS; IMMUNITY; DIFFERENTIATION; EXPRESSION; PROGNOSIS;
Keywords:
dendritic cells; Langerhans' cells; larynx; precancerous lesions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sprinzl, GM Innsbruck Univ, Dept Otorhinolaryngol Head & Neck Surg, Anichstr 35, A-6020 Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 , Austria
Citazione:
G.M. Sprinzl et al., "Dendritic cells in precancerous lesions of the larynx", LARYNGOSCOP, 110(1), 2000, pp. 13-18

Abstract

Objectives: Hyperplastic lesions of the laryngeal mucosa can eventually develop into squamous cell carcinoma. The relationship between dendritic cell. infiltration of head and neck cancers and prognosis is well known. Surprisingly, data regarding dendritic cell infiltration in precancerous lesions are not available today. It was the purpose of our study to extend these observations and to investigate in more detail the density and distribution of dendritic cells in precancerous lesions. Study Design: Retrospective survey by immunohistochemistry. Methods: For this study we investigated paraffin-embedded tissue sections of 41 specimens, Histological diagnosis disclosed precancerous lesions of the larynx in 34 cases and in 7 cases, squamous cell carcinoma. Immunohistochemical study was performed using antibodies against the cell surface markers S-100, HLA-DR, CD20, CD45 RO, CD45 RA, and Lag. Typical dendritic cell distributions of the immunostained specimens werephotographed and measured on a quantitative basis. The medical histories of the patients were then analyzed retrospectively. Results: HLA-DR+ cells could be detected in 14 of 16 cases in mild dysplastic lesions. The infiltration of the dysplastic lesions was sparse compared to cases with higher-graded dysplastic lesions. The distribution patterns of the dendritic cells inspecimens with severe dysplastic lesions, but squamous cell carcinoma wereextremely similar and markedly different from those in grades I and II specimens. Memory T lymphocytes (CD45 RO+) were detected more often in the group with severe dysplastic lesions (8 of 9 cases) than in the group with squamous cell carcinoma (3 of 8 cases). The inverse became evident for CD20 and CD45 RA immunolabeling. Conclusions: Few dendritic cells were found in the precancerous lesions, This may suggest that these early lesions (grades Iand II) are not efficiently monitored by the immune system. Therefore theymay develop into carcinomas unimpaired by cytotoxic T cells. As the degreeof malignancy rises (grade III), more dendritic cells infiltrate the tumor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:12:20