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Titolo:
Does prostaglandin E1 therapy modify the intracavernous musculature?
Autore:
Wespes, E; Sattar, AA; Noel, JC; Schulman, CC;
Indirizzi:
Free Univ Brussels, Erasme Hosp, Dept Urol, B-1050 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1050 rol, B-1050 Brussels, Belgium Free Univ Brussels, Erasme Hosp, Dept Pathol, B-1050 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1050 hol, B-1050 Brussels, Belgium CHU Charleroi, Dept Urol, Charleroi, Belgium CHU Charleroi Charleroi Belgium harleroi, Dept Urol, Charleroi, Belgium
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 2, volume: 163, anno: 2000,
pagine: 464 - 466
SICI:
0022-5347(200002)163:2<464:DPETMT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INJECTION THERAPY; PENILE FIBROSIS; ERECTILE DYSFUNCTION; IMPOTENCE; HYPOXEMIA; DISEASE;
Keywords:
impotence; alprostadil; injections;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Wespes, E Bd Pauk Janson 92,6000 Charleroi, Brussels, Belgium Bd Pauk Janson 92,6000 Charleroi Brussels Belgium ls, Belgium
Citazione:
E. Wespes et al., "Does prostaglandin E1 therapy modify the intracavernous musculature?", J UROL, 163(2), 2000, pp. 464-466

Abstract

Purpose: Intracavernous injection of prostaglandin E1 in patients with erectile dysfunction has become widespread. However, to our knowledge long-term side effects on the penile smooth muscles in man have not been documented. We evaluated the histological changes of intracavernous smooth muscle after long-term treatment with prostaglandin E1. Materials and Methods: A total of 10 patients with a mean age of 56.5 years (range 46 to 69) underwent biopsy of the corpora before (5) and after (10in both corpora) prostaglandin E1 treatment. Between 150 and 250 injections during 3 years were performed, and the dosage varied from 5 to 20 mu g. Only 1 patient injected prostaglandin E1 on both sides. Staining with hematoxylin and eosin, and immunohistochemical staining with actin anti-actin of intracavernous smooth muscle and its quantification with computerized imageanalysis were performed. Results: No histological difference was observed with classic staining. A reduction was noted in the percentage of intracavernous smooth muscle aftertreatment in 2 of 5 patients on the side of injection (before 35% and 41%,and after 19% and 30%, respectively) but there was no difference with the other corpus cavernosum No difference was observed in the percentage of intracavernous smooth muscle between both corpora in the 5 patients with biopsies performed only after treatment. Conclusions: Prostaglandin E1 does not seem to alter intracavernous structures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:01:21