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Titolo:
Is there a relationship between serum S-100 beta protein and neuropsychologic dysfunction after cardiopulmonary bypass?
Autore:
Westaby, S; Saatvedt, K; White, S; Katsumata, T; van Oeveren, W; Bhatnagar, NK; Brown, S; Halligan, PW;
Indirizzi:
John Radcliffe Hosp, Oxford Heart Ctr, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Ctr, Oxford OX3 9DU, England Univ Groningen, Dept Biomed Engn, Groningen, Netherlands Univ Groningen Groningen Netherlands iomed Engn, Groningen, Netherlands Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England
Titolo Testata:
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
fascicolo: 1, volume: 119, anno: 2000,
pagine: 132 - 137
SICI:
0022-5223(200001)119:1<132:ITARBS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY BYPASS; CARDIAC-SURGERY; BRAIN MICROEMBOLI; CEREBRAL INJURY; MARKER; OPERATIONS; INFARCTION; EMBOLI; STROKE; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Westaby, S John Radcliffe Hosp, Oxford Heart Ctr, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU d OX3 9DU, England
Citazione:
S. Westaby et al., "Is there a relationship between serum S-100 beta protein and neuropsychologic dysfunction after cardiopulmonary bypass?", J THOR SURG, 119(1), 2000, pp. 132-137

Abstract

Objectives: Over the past decade, the glial protein S-100 beta has been used to detect cerebral injury in a number of clinical settings including cardiac surgery. Previous investigations suggest that S-100 beta is capable ofidentifying patients with cerebral dysfunction after cardiopulmonary bypass. Whether detection of elevated levels S-100 beta reflects long-term cognitive impairment remains to be shown. The present study evaluated whether perioperative release of S-100 beta after coronary artery operations with cardiopulmonary bypass could predict early or late neuropsychologic impairment. Methods: A total of 100 patients undergoing elective coronary bypass without a previous history of neurologic events were prospectively studied. To exclude noncerebral sources of S-100 beta, we did not use cardiotomy suction or retransfusion of shed mediastinal blood. Serial perioperative measurements of S-100 beta were performed with the use of a new sensitive immunoluminometric assay up to 8 hours after the operation. Patients underwent cognitive testing on a battery of 11 tests before the operation, before discharge from the hospital, and 3 months later. Results: No significant correlation was found between S-100 beta release and neuropsychologic measures either5 days or 3 months after the operation, Conclusion: Despite using a sensitive immunoluminometric assay of S-100 beta, we found no evidence to supportthe suggestion that early release of S-100 beta may reflect long-term neurologic injury capable of producing cognitive impairment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:08:16