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Titolo:
LMP2 polymorphism is associated with extraspinal disease in HLA-B27 negative Caucasian and Mexican Mestizo patients with ankylosing spondylitis
Autore:
Maksymowych, WP; Tao, S; Vaile, J; Suarez-Almazor, M; Ramos-Remus, C; Russell, AS;
Indirizzi:
Univ Alberta, Dept Med, Heritage Med Res Ctr 562, Edmonton, AB T6G 2S2, Canada Univ Alberta Edmonton AB Canada T6G 2S2 562, Edmonton, AB T6G 2S2, Canada Univ Alberta, Dept Publ Hlth Sci, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada Dept Publ Hlth Sci, Edmonton, AB, Canada Hosp Especialidades, IMSS, Dept Rheumatol, Guadalajara, Jalisco, Mexico Hosp Especialidades Guadalajara Jalisco Mexico dalajara, Jalisco, Mexico
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 1, volume: 27, anno: 2000,
pagine: 183 - 189
SICI:
0315-162X(200001)27:1<183:LPIAWE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; ACUTE ANTERIOR UVEITIS; HLA-ANTIGENS; CLASS-II; LINKAGE DISEQUILIBRIUM; SUSCEPTIBILITY; ARTHRITIS; GENES; MHC; SPONDYLOARTHROPATHIES;
Keywords:
HLA-B27 negative; ankylosing spondylitis; LMP2 polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Maksymowych, WP Univ Alberta, Dept Med, Heritage Med Res Ctr 562, Edmonton, AB T6G 2S2, Canada Univ Alberta Edmonton AB Canada T6G 2S2 B T6G 2S2, Canada
Citazione:
W.P. Maksymowych et al., "LMP2 polymorphism is associated with extraspinal disease in HLA-B27 negative Caucasian and Mexican Mestizo patients with ankylosing spondylitis", J RHEUMATOL, 27(1), 2000, pp. 183-189

Abstract

Objective. To determine the effects of HLA Class II genes, particularly LMP2 and previously implicated Class I genes, on susceptibility and disease expression in HLA-B27 negative ankylosing spondylitis (AS). Methods, Patients included 41 HLA-B27 negative Caucasians from a total AS population of 546 and 17 HLA-B27 negative Mexican Mestizo. Controls included 4352 random HLA-B27 negative Caucasians. LMP2 genotype assignments were made on all patients and 282 random Caucasian controls by polymerase chain reaction-restriction fragment length polymorphism with the Cfo I restrictionenzyme while HLA typing was performed on patients and controls using microcytotoxicity assays for Class I, and sequence specific probe-PCR for HLA-B60, B39, B38, and DR. Results, The LMP2BB genotype was significantly decreased in Caucasian AS patients without extraspinal (ES) disease (25%) compared to AS patients withES (64.7%) (p = 0.01) and random Caucasian controls (53.9%) (p = 0.007), even when those with colitis and psoriasis were excluded from analysis (ES 55.6% versus ES - 22.2%). This finding remained significant after stratification by HLA-DR. Similar trends were noted in the Mexican population. A potential role for HLA-DR8 and DR2 in susceptibility to disease was observed in Caucasian patients, although this observation requires confirmation. We could nor confirm reported associations with HLA-B60 or B39. Peripheral arthritis was significantly more commonly observed in those who had had acute anterior uveitis (AAU) (75%) than in those who had not developed AAU (27.3%) (p = 0.04). Conclusion. HLA Class II encoded genes may have effects on disease susceptibility and/or phenotype in HLA-B27 negative individuals similar to those noted in HLA-B27 positive AS. Eccentric and axial phenotypes of disease may be immunogenetically determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:26:56