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Titolo:
Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers
Autore:
Kumari, V; Cotter, PA; Mulligan, OF; Checkley, SA; Gray, NS; Hemsley, DR; Thornton, JC; Corr, PJ; Toone, BK; Gray, JA;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Inst Psychiat, Dept Psychol, London SE5 8AF, England Inst Psychiat London England SE5 8AF pt Psychol, London SE5 8AF, England Inst Psychiat, Dept Psychiat, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Psychiat, London SE5 8AF, England Inst Psychiat, Sect Cognit Psychopharmacol, London SE5 8AF, England Inst Psychiat London England SE5 8AF opharmacol, London SE5 8AF, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 13, anno: 1999,
pagine: 398 - 405
SICI:
0269-8811(199912)13:4<398:EODAHO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC ATTENTION DISORDER; ACOUSTIC STARTLE REFLEX; PRONE NORMAL SUBJECTS; PREEXPOSURE DURATION; IRRELEVANT STIMULI; NUCLEUS-ACCUMBENS; RATS; NICOTINE; DOPAMINE; PEOPLE;
Keywords:
d-amphetamine; dopamine; haloperidol; latent inhibition; psychoticism; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Kumari, V Inst Psychiat, Dept Psychol Med, Sect Cognit Psychopharmacol, DeCrespignyPk, London SE5 8AF, England Inst Psychiat De Crespigny Pk LondonEngland SE5 8AF F, England
Citazione:
V. Kumari et al., "Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers", J PSYCHOPH, 13(4), 1999, pp. 398-405

Abstract

Latent inhibition (LI) refers to a retardation of learning about the consequences of a stimulus when that stimulus has been passively presented a number of times without reinforcement. Acute positive-symptom schizophrenics, normal volunteers who score high on questionnaire measures of schizotypy and non-patients or animals treated with dopamine agonists show reduced LI. Neuroleptic drugs, such as haloperidol, administered at low doses, potentiate LI and effectively reverse disruption of LI induced by dopamine agonists in animals. However, a high dose of haloperidol, administered on its own, has been found to reduce LI. We examined the effects on LI of acute oral administration of an indirect dopamine-agonist, d-amphetamine (5 mg), and a nonselective dopamine receptor antagonist, haloperidol (5 mg), in normal malevolunteers, using an associative learning task. Replicating previous reports, we found that d-amphetamine reduced LI; haloperidol also reduced LI, but only in subjects who scored low on the Psychoticism. scale of the EysenckPersonality Questionnaire. In a subsequent study no effect was found of 2 mg oral haloperidol administration on LI. The effect of 5 mg haloperidol onLI is interpreted as similar to that observed with a high dose of haloperidol in rats.

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Documento generato il 20/01/20 alle ore 11:03:45