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Titolo:
Comparison of the effects of alpha-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo
Autore:
McTavish, SFB; Callado, L; Cowen, PJ; Sharp, T;
Indirizzi:
Univ Oxford, Dept Clin Pharmacol, Radcliffe Infirm, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX liffe Infirm, Oxford OX3 7JX, England Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England Univ Oxford Oxford England rneford Hosp, Dept Psychiat, Oxford, England Univ Basque Country, Dept Pharmacol, Bilbao, Spain Univ Basque Country Bilbao Spain Country, Dept Pharmacol, Bilbao, Spain
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 13, anno: 1999,
pagine: 379 - 384
SICI:
0269-8811(199912)13:4<379:COTEOA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPTOPHAN; BRAIN; PHENYLALANINE; MICRODIALYSIS; DEPLETION; 5-HT;
Keywords:
alpha-methyl-p-tyrosine; idazoxan; microdialysis; noradrenaline; tyrosine depletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: McTavish, SFB Univ Oxford, Dept Clin Pharmacol, Radcliffe Infirm, Woodstock Rd, Oxford OX3 7JX, England Univ Oxford Woodstock Rd Oxford England OX3 7JX JX, England
Citazione:
S.F.B. McTavish et al., "Comparison of the effects of alpha-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo", J PSYCHOPH, 13(4), 1999, pp. 379-384

Abstract

Peripheral administration of an amino acid load lacking tyrosine and its precursor, phenylalanine, causes a lowering of central tyrosine levels. The aim of the present study was to examine the effects of tyrosine depletion on extracellular noradrenaline using microdialysis. Extracellular noradrenaline was measured in hippocampus of the anaesthetized rat under both baseline conditions (with reuptake inhibitor, desipramine, in the perfusion medium) and following administration of the as-adrenoreceptor antagonist, idazoxan. The tyrosine free amino acid load did not alter either baseline noradrenaline or the twofold rise in noradrenaline evoked by idazoxan compared withsaline controls. In contrast, the catecholamine synthesis inhibitor, alpha-methyl-p-tyrosine, caused a marked reduction in baseline extracellular noradrenaline and abolished the rise induced by idazoxan. In conclusion, the present data indicate that under the conditions used, a tyrosine-free amino acid mixture may not be an effective means to interfere with central noradrenaline function. This contrasts with recent findings demonstrating that the tyrosine-depletion approach can be used to decrease presynaptic dopamine function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:37:58