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Titolo:
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies
Autore:
Laruelle, M; Abi-Dargham, P;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA New York State Psychiat Inst, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 13, anno: 1999,
pagine: 358 - 371
SICI:
0269-8811(199912)13:4<358:DATWOT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; VENTRAL TEGMENTAL AREA; C-11 RACLOPRIDE BINDING; IN-VIVO MICRODIALYSIS; FREELY MOVING RATS; ENDOGENOUS DOPAMINE; STRIATAL DOPAMINE; NONHUMAN-PRIMATES; BASAL GANGLIA;
Keywords:
dopamine D-2 receptors; psychostimulants; schizophrenia; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
109
Recensione:
Indirizzi per estratti:
Indirizzo: Laruelle, M Columbia Univ, Dept Psychiat, New York State Psychiat Inst, Unit 42, 1051 Riverside Dr, New York, NY 10032 USA Columbia Univ 1051 Riverside Dr New York NY USA 10032 0032 USA
Citazione:
M. Laruelle e P. Abi-Dargham, "Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies", J PSYCHOPH, 13(4), 1999, pp. 358-371

Abstract

Abnormalities of dopamine function in schizophrenia are suggested by the common antidopaminergic properties of antipsychotic medications. However, direct evidence of a hyperdopaminergic state in schizophrenia has been difficult to demonstrate, given the difficulty of measuring dopamine transmissionin the living human. brain. This situation is rapidly changing. Recent developments in positron emission tomography and single-photon emission tomographic techniques enabled measurement of acute fluctuation of synaptic dopamine in. the vicinity of D-2 receptors. Using this technique, we, and others, measured the increase in dopamine transmission following acute amphetamine challenge in untreated patients with schizophrenia and matched healthy subjects. Following a brief overview of these new brain imaging techniques, the main results derived with this method in patients with schizophrenia aredescribed: (1) amphetamine-induced dopamine release is elevated in patients with schizophrenia, supporting the idea that schizophrenia is associated with dysregulation of dopamine transmission; (2) following amphetamine, hyperactivity of dopamine transmission is associated with activation of psychotic symptomatology; (3) this dysregulation of dopamine release is not a long-term consequence of previous neuroleptic treatment, and is detected in never-medicated patients experiencing a first episode of the illness; and (4)in contrast, this exaggerated response of the dopamine system to amphetamine exposure is not detected in patients studied during a period of illness stabilization, suggesting that the hyperdopaminergic state associated with schizophrenia fluctuates over time. In conclusion, a hyperdopaminergic state might be present in schizophrenia during the initial episode and subsequent relapses, but not during periods of remission. This finding has important consequences for the development of new treatment, strategies for the remission phase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:57:42