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Titolo:
Capsaicin inhibits the pentagastrin-stimulated gastric acid secretion in anaesthetized rats with acute gastric fistula
Autore:
Abdel-Salam, OME; Debreceni, A; Szolcsanyi, J; Mozsik, G;
Indirizzi:
Med Univ Pecs, Dept Med 1, Pecs, Hungary Med Univ Pecs Pecs HungaryMed Univ Pecs, Dept Med 1, Pecs, Hungary Med Univ Pecs, Dept Pharmacol & Pharmacotherapy, Pecs, Hungary Med Univ Pecs Pecs Hungary t Pharmacol & Pharmacotherapy, Pecs, Hungary
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 5, volume: 93, anno: 1999,
pagine: 461 - 466
SICI:
0928-4257(199911)93:5<461:CITPGA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; MUCOSAL BLOOD-FLOW; SENSITIVE AFFERENT NEURONS; INTRAGASTRIC CAPSAICIN; SUBSTANCE-P; STOMACH; RELEASE; SOMATOSTATIN; HISTAMINE; RESPONSES;
Keywords:
capsaicin; pentagastrin; gastric acid secretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Mozsik, G Med Univ Pecs, Dept Med 1, Pecs, Hungary Med Univ Pecs Pecs Hungary iv Pecs, Dept Med 1, Pecs, Hungary
Citazione:
O.M.E. Abdel-Salam et al., "Capsaicin inhibits the pentagastrin-stimulated gastric acid secretion in anaesthetized rats with acute gastric fistula", J PHYSL-PAR, 93(5), 1999, pp. 461-466

Abstract

The effect of capsaicin on basal and pentagastrin-stimulated gastric acid secretion was investigated in the urethane anaesthetized acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric lumen with saline every 15 min or by continuous gastric perfusion. Capsaicin given into the rat stomach at 120 ng.mL(-1) prior to pentagastrin (25 mu g.kg(-1), iv) reduced gastric acid secretory response to pentagastrin by 24%. Intravenous (iv) capsaicin (0.5 mu g.kg(-1)) did not reduce the pentagastrin-stimulated gastric acid secretion. After topical capsaicin desensitization (3 mg.mL(-1)), basal gastric acid secretion and that in response to pentagastrin (25 mu g.kg(-1), intraperitonaeally) was unaltered compared with the control group. Data indicate that topical capsaicin inhibits gastric acidsecretion stimulated with pentagastrin in anaesthetized rats. (C) 1999 Elsevier Science Ltd. Published by Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:54:06