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Titolo:
Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents
Autore:
Abdel-Salam, OME; Debreceni, A; Mozsik, G; Szolcsanyi, J;
Indirizzi:
Med Univ Pecs, Dept Med 1, H-7643 Pecs, Hungary Med Univ Pecs Pecs Hungary H-7643 Pecs, Dept Med 1, H-7643 Pecs, Hungary Med Univ Pecs, Dept Pharmacol, H-7643 Pecs, Hungary Med Univ Pecs Pecs Hungary H-7643 , Dept Pharmacol, H-7643 Pecs, Hungary
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 5, volume: 93, anno: 1999,
pagine: 443 - 454
SICI:
0928-4257(199911)93:5<443:CASNIM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; ACID SECRETORY RESPONSES; EPIDERMAL GROWTH-FACTOR; PERFUSED RAT STOMACH; BLOOD-FLOW; INTRAGASTRIC CAPSAICIN; ARTERIOLAR DILATION; ANESTHETIZED RATS; VAGAL AFFERENTS; BILE-SALTS;
Keywords:
capsaicin; resiniferatoxin; gastric ulcer; gastrointestinal blood flow; gastric acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Mozsik, G Med Univ Pecs, Dept Med 1, Ifjusag Ut, H-7643 Pecs, Hungary Med Univ Pecs Ifjusag Ut Pecs Hungary H-7643 7643 Pecs, Hungary
Citazione:
O.M.E. Abdel-Salam et al., "Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents", J PHYSL-PAR, 93(5), 1999, pp. 443-454

Abstract

In the rat stomach, evidence has been provided that capsaicin-sensitive sensory nerves (CSSN) are involved in a local defense mechanism against gastric ulcer. In the present study capsaicin or resiniferatoxin (RTX), a more potent capsaicin analogue, was used to elucidate the role of these sensory nerves in gastric mucosal protection, mucosal permeability, gastric acid secretion and gastrointestinal blood Row in the rat. In the rat stomach and jejunum, intravenous RTX or topical capsaicin or RTX effected a pronounced and long-lasting enhancement of the microcirculation at these sites, measuredby laser Doppler flowmetry technique. Introduction of capsaicin into the rat stomach in very low concentrations of ng-mu g.mL(-1) range protected thegastric mucosa against damage produced by topical acidified aspirin, indomethacin, ethanol or 0.6 N HCl. Resiniferatoxin exhibited acute gastroprotective effect similar to that of capsaicin and exerted marked protective action on the exogenous HCl, or the secretagogue-induced enhancement of the indomethacin injury. The ulcer preventive effect of both agents was not prevented by atropine or cimetidine treatment. Capsaicin given into the stomach in higher desensitizing concentrations of 6.5 mM markedly enhanced the susceptibility of the gastric mucosa and invariably aggravated gastric mucosal damage evoked by later noxious challenge. Such high desensitizing concentrations of capsaicin, however, did not reduce the cytoprotective effect of prostacyclin (PGI,) or beta-carotene. Capsaicin or RTX had an additive protective effect to that of atropine or cimetidine. In rats pretreated with cysteamine to deplete tissue somatostatin, capsaicin protected against the indomethacin-induced mucosal injury. Gastric acid secretion of the pylorus-ligated rats was inhibited with capsaicin or RTX given in low non-desensitizing concentrations, with the inhibition being most marked in the first hour following pylorus-ligation. Low intragastric concentrations of RTX reduced gastric hydrogen ion back-diffusion evoked by topical acidified salicylates. It is concluded that the gastropotective effect of capsaicin-type agents involves primarily an enhancement of the microcirculation effected through local release of mediator peptides from the sensory nerve terminals. A reduction in gastric acidity may contribute to some degree in the gastric protective action of capsaicin-type agents. The vasodilator and gastroprotective effects of capsaicin-type agents do not depend on vagal efferents or sympathetic neurons, involve prostanoids, histaminergic or cholinergic pathways. (C) 1999 Elsevier Science Ltd. Published by Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:31:33