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Titolo:
Pentadecapeptide BPC 157 attenuates gastric lesions induced by alloxan in rats and mice
Autore:
Petek, M; Sikiric, P; Anic, T; Buljat, G; Separovic, J; Stancic-Rokotov, D; Seiwerth, S; Grabarevic, Z; Rucman, R; Mikus, D; Zoricic, I; Prkacin, I; Sebecic, B; Ziger, T; Coric, V; Turkovic, B; Aralica, G; Rotkvic, I; Mise, S; Hahn, V;
Indirizzi:
Univ Zagreb, Fac Med, Dept Pharmacol, Zagreb 10000, Croatia Univ Zagreb Zagreb Croatia 10000 , Dept Pharmacol, Zagreb 10000, Croatia
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 6, volume: 93, anno: 1999,
pagine: 501 - 504
SICI:
0928-4257(199912)93:6<501:PB1AGL>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRAINT STRESS; NITRIC-OXIDE; BPC-157; PEPTIDE; MUCOSA;
Keywords:
pentadecapeptide BPC 157; alloxan; protection; gastric lesions; rats; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sikiric, P Univ Zagreb, Fac Med, Dept Pharmacol, Solata 11,POB 916, Zagreb10000, Croatia Univ Zagreb Solata 11,POB 916 Zagreb Croatia 10000 00, Croatia
Citazione:
M. Petek et al., "Pentadecapeptide BPC 157 attenuates gastric lesions induced by alloxan in rats and mice", J PHYSL-PAR, 93(6), 1999, pp. 501-504

Abstract

A diabetogenic alloxan regimen produced lesions in all stomachs of treatedanimals, either rats (200 mg.kg(-1) s.c.) or mice (400 mg.kg(-1) i.p.). Incontrol animals, the lesions, when developed (i.e. 24 h following application), appear to be quite sustained, and consistently present also after 1 or 2 weeks. The application of the pentadecapeptide BPC 157 (10 mu g or 10 ng.kg(-1) i.p. coadministered together with alloxan) would significantly attenuate these lesions' appearance. This beneficial effect seems to be present in either rats or mice and in either of the tested intervals. Importantly, the beneficial effect seems to be shared by both microgram and nanogram regimens. (C) 1999 Elsevier Science Ltd. Published by Editions scientifiqueset medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:04:13