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Titolo:
The effect of pentadecapeptide BPC 157, H-2-blockers, omeprazole and sucralfate on new vessels and new granulation tissue formation
Autore:
Sikiric, P; Separovic, J; Anic, T; Buljat, G; Mikus, D; Seiwerth, S; Grabarevic, Z; Stancic-Rokotov, D; Pigac, B; Hanzevacki, M; Marovic, A; Rucman, R; Petek, M; Zoricic, I; Ziger, T; Aralica, G; Konjevoda, P; Prkacin, I; Gjurasin, M; Miklic, P; Artukovic, B; Tisljar, M; Bratulic, M; Mise, S; Rotkvic, I;
Indirizzi:
Univ Zagreb, Med & Vet Fac, HR-1000 Zagreb, Croatia Univ Zagreb Zagreb Croatia HR-1000 ed & Vet Fac, HR-1000 Zagreb, Croatia
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 6, volume: 93, anno: 1999,
pagine: 479 - 485
SICI:
0928-4257(199912)93:6<479:TEOPB1>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRAINT STRESS; NITRIC-OXIDE; BPC-157; LESIONS; RATS; PEPTIDE; ETHANOL; CYSTEAMINE; CIMETIDINE; MUCOSA;
Keywords:
pentadecapeptide BPC 157; angiogenesis; granulation; promotion; H-2-blockers; omeprazole; sucralfate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sikiric, P Univ Zagreb, Med & Vet Fac, HR-1000 Zagreb, Croatia Univ Zagreb Zagreb Croatia HR-1000 c, HR-1000 Zagreb, Croatia
Citazione:
P. Sikiric et al., "The effect of pentadecapeptide BPC 157, H-2-blockers, omeprazole and sucralfate on new vessels and new granulation tissue formation", J PHYSL-PAR, 93(6), 1999, pp. 479-485

Abstract

A clear protection of the gastrointestinal tract and an evident anti-inflammatory effect were shown for a novel stomach pentadecapeptide BPC 157 (i.p./i.g.) in comparison with several reference standards in various ulcer models along with a protection of endothelium and particular interaction with the NO-system. Thus, we evaluated whether this pentadecapeptide along with other gastroprotective agents could affect angiogenesis and the healing process in vivo using a procedure initially described by Szabo and co-workers. In each rat, two sterile sponges (1 x 1 x 0.25 cm; V = 0.25 mt) with the same quantities of BPC 157 (10 ng.mL(-1), 10 mu g.mL(-1), 50 mu g.kg(-1)) orreference agents (cimetidine: 10, 100, 500 mg.mL(-1); ranitidine: 2.5, 25,250 mg.mL(-1); famotidine: 10, 50, 100 mg.mL(-1); omeprazole: 10, 50, 100 mg.mL(-1); sucralfate: 1, 5, 10 mg.mL(-1)) were implanted subcutaneously inthe lumbar region. The sponges were removed after 3 or 7 d, fixed in formalin, and processed for histologic and histochemical evaluation and morphometry assessment. Compared with the control values, the number of newly formed endothelial spaces inside newly formed granulation tissue was markedly increased in all animals treated with BPC 157, cimetidine, ranitidine, famotidine, sucralfate and omeprazole, a consistent finding noted after either 3 or 7 d. Compared with control values, markedly more granulation tissue was noted in the rats in the groups of animals treated with BPC 157 (50 mu g) and in the rats treated with sucralfate in all dosages used, euthanized after 3 d. In all groups treated with H-2-blockers however, similar values to those of controls were noted. Thus, it could be concluded that an evident angiogenic property was consistently noted for the novel pentadecapeptide BPC157, H-2-blockers (cimetidine, famotidine and ranitidine) and omeprazole, besides the well known angiogenic effect of sucralfate. Furthermore, unlikeH-2-blockers and omeprazole, BPC 157 stimulates the formation of granulation tissue, suggesting a particular activity, similar to that previously noted for sucralfate. (C) 1999 Elsevier Science Ltd. Published by Editions scientifiques et medicales Elsevier SAS.

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Documento generato il 07/07/20 alle ore 22:07:35