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Titolo:
Upregulation of putaminal dopamine D-2 receptors in early Parkinson's disease: A comparative PET study with [C-11]raclopride and [C-11]N-methylspiperone
Autore:
Kaasinen, V; Ruottinen, HM; Nagren, K; Lehikoinen, P; Oikonen, T; Rinne, JO;
Indirizzi:
Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Neurol, FIN-20520 Turku, Finland Turku PET Ctr, Radiopharmaceut Chem Lab, Turku, Finland Turku PET Ctr Turku Finland r, Radiopharmaceut Chem Lab, Turku, Finland
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 41, anno: 2000,
pagine: 65 - 70
SICI:
0161-5505(200001)41:1<65:UOPDDR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 METHYL TRIFLATE; H-3 RACLOPRIDE; ENDOGENOUS DOPAMINE; HUMAN-BRAIN; BINDING; DENSITY; MPTP; SUPERSENSITIVITY; STRIATUM;
Keywords:
Parkinson's disease; dopamine D-2 receptor; raclopride; N-methylspiperone; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Rinne, JO Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 l, FIN-20520 Turku, Finland
Citazione:
V. Kaasinen et al., "Upregulation of putaminal dopamine D-2 receptors in early Parkinson's disease: A comparative PET study with [C-11]raclopride and [C-11]N-methylspiperone", J NUCL MED, 41(1), 2000, pp. 65-70

Abstract

Dopamine D-2 receptor function was assessed in a PET study with 2 dopamineD-2 receptor PET ligands, [C-11]raclopride (RAG) and [C-11]N-methylspiperone (NMSP), in early Parkinson's disease. Methods: Seven patients with earlyParkinson's disease and 5 healthy volunteers were studied. Each underwent PET both with reversible [C-11]RAC and with irreversible [C-11]NMSP. Results: Upregulation of dopamine D-2 receptors in the putamen contralateral to the predominant symptoms of Parkinson's disease was confirmed using both [C-11]RAC and [C-11]NMSP. Uptake of [C-11]RAC in the contralateral putamen was105% of uptake in the opposite putamen (P = 0.020). For [C-11]NMSP, uptakein the contralateral putamen was 105% of uptake in the ipsilateral putamen(P = 0.011). No significant differences between Parkinson's disease patients and healthy volunteers were detected in any of the studied brain regionsusing either [C-11]RAC or [C-11]NMSP. No significant differences between [C-11]RAC and [C-11]NMSP uptake were detected in the striatum, whereas in the extrastriatal regions, [C-11]NMSP showed significantly higher uptake than[C-11]RAC both in healthy volunteers and in Parkinson's disease patients. Conclusion: This study confirms an increase in dopamine D-2 receptors in the putamen contralateral to the predominant symptoms, compared with the ipsilateral putamen, in early Parkinson's disease. This increase was seen both with reversible ligand [C-11]RAC and with irreversible ligand [C-11]NMSP and thus does not seem a consequence of depleted endogenous dopamine.

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Documento generato il 18/01/20 alle ore 10:31:21