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Titolo:
Transient prolonged stunning induced by dipyridamole and shown on 1-and 24-hour poststress Tc-99m-MIBI gated SPECT
Autore:
Lee, DS; Yeo, JS; Chung, JK; Lee, MM; Lee, MC;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Nucl Med, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 Med, Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 Med, Seoul 110744, South Korea
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 41, anno: 2000,
pagine: 27 - 35
SICI:
0161-5505(200001)41:1<27:TPSIBD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL PERFUSION; EJECTION FRACTION; SESTAMIBI; ECHOCARDIOGRAPHY; QUANTIFICATION; TOMOGRAMS; MOTION;
Keywords:
gated myocardial SPECT; stunning; dipyridamole stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, DS Seoul Natl Univ, Coll Med, Dept Nucl Med, 28 Yungundong Chongnogu,Seoul 110744, South Korea Seoul Natl Univ 28 Yungundong Chongnogu Seoul South Korea 110744
Citazione:
D.S. Lee et al., "Transient prolonged stunning induced by dipyridamole and shown on 1-and 24-hour poststress Tc-99m-MIBI gated SPECT", J NUCL MED, 41(1), 2000, pp. 27-35

Abstract

We investigated whether poststress gated SPECT, which was believed to showresting wall motion, revealed stunning induced by dipyridamole stress. Methods: In 62 patients with coronary artery disease (n = 57) or chest pain (n= 5), dipyridamole stress gated Tc-99m-hexakis-2-methoxyisobutyl isonitrile (MIBI) SPECT and rest(201)Tl SPECT were performed on the first day; 24-h delayed Tl-201 SPECT and rest gated Tc-99m-MIBI SPECT were performed on thesecond day. Stress and rest gated Tc-99m-MIBI SPECT was performed 1 h after injection. The myocardium was divided into 17 segments, and perfusion wasscored on a 4-point scoring system (scores, 0-3 for normal to defect); wall motion during first-day poststress gated and second-day rest gated SPECT was also scored on another 4-point scale (scores, 0-3 for normal to dyskinesia). Results: Thirty-one of 62 patients showed wall motion abnormality that was worse after stress than during resting. Three hundred eight (29%) of the total 1054 segments showed wall motion abnormality on poststress gated SPECT. In 198 of these segments, wall motion abnormality was the same on poststress and rest gated SPECT, and 106 segments showed wall motion that wasworse on I-h poststress than on rest gated SPECT. Perfusion was normal either during rest (n = 113) or after a 24-h delay (n = 18) in 131 segments with the poststress wall motion abnormality. Of these 131 segments, 69 showedthe same wall motion abnormality between poststress and resting periods (persistent stunning). However, in 40 segments, abnormal wall motion on I-h post-stress gated SPECT normalized on rest gated SPECT (transient prolonged stunning). The other 20 segments showed improvement of wall motion during rest compared with the poststress period but still showed abnormal wall motion during the resting period (between transient prolonged stunning and persistent stunning). Stress perfusion decrease was more severe in transient prolonged stunning than in persistent stunning. Poststress wall motion abnormality was more severe in persistent stunning. Conclusion: Using gated Tc-99m-MIBI SPECT, stunned myocardium was found on 1-h poststress SPECT comparedwith normal resting wall motion found on rest gated SPECT on the next day. We conclude that some myocardial walls did not show true resting wall motion on 1-h poststress gated SPECT; hence, caution is necessary when using wall motion on 1-h poststress gated SPECT to assess resting wall motion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:22:40