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Titolo:
Clinical application of Tl-201 SPECT imaging of brain tumors
Autore:
Sun, D; Liu, QC; Liu, WG; Hu, WW;
Indirizzi:
Zhejiang Univ, Second Hosp, Coll Med, Dept Nucl Med, Hangzhou 310009, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310009 ou 310009, Peoples R China Zhejiang Univ, Second Hosp, Coll Med, Dept Neurosurg, Hangzhou 310009, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310009 ou 310009, Peoples R China
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 41, anno: 2000,
pagine: 5 - 10
SICI:
0161-5505(200001)41:1<5:CAOTSI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
THALLIUM 201; GLIOMAS; TECHNETIUM-99M-HMPAO; DIAGNOSIS; GRADE;
Keywords:
Tl-201 SPECT; brain tumor; Tl-201 retained index;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, D Zhejiang Univ, Second Hosp, Coll Med, Dept Nucl Med, Hangzhou 310009, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310009 09, Peoples R China
Citazione:
D. Sun et al., "Clinical application of Tl-201 SPECT imaging of brain tumors", J NUCL MED, 41(1), 2000, pp. 5-10

Abstract

This study investigated the clinical usefulness of evaluating the histologic grade of brain tumors by Tl-201 SPECT brain imaging. Methods: Early and delayed SPECT brain images were obtained about 10 min and 3 h, respectively, after intravenous injection of 111MBq (3 mCi) Tl-201 in 9 healthy subjects (control subjects), 3 patients with brain hematomas, and 41 patients withbrain tumors. Semiquantitative data were obtained for early and delayed Tl-201 uptake indices and Tl-201 retained index in all patients and healthy subjects. Results: In 9 healthy subjects, there was little radioactivity in brain substance. In all patients with brain hematomas or tumors, a high tracer uptake was visible in lesions on early images, but the radioactivity inlesions varied with the histologic nature of the lesion on delayed images. The radioactivity decreased remarkably in brain hematomas (average retained index, 0.61 +/- 0.04). The radioactivity was stable or decreased slightlyin benign or low-grade tumors (average retained index, 0.96 +/- 0.24). Theradioactivity was increased in high-grade or metastatic tumors (average retained index, 1.26 +/- 0.28). Conclusion: This study indicates that Tl-201 brain SPECT early and delayed imaging is very useful in brain tumor localization, in distinguishing low-grade from high-grade brain tumors, in predicting histologic grades of brain tumors, and in detecting residual or recurrence of brain tumors postoperatively. Tl-201 brain SPECT may also offer the most accurate assessment of response to therapy.

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Documento generato il 28/03/20 alle ore 23:30:53