Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The contribution of fast-FLAIR MRI for lesion detection in the brain of patients with systemic autoimmune diseases
Autore:
Rovaris, M; Inglese, M; Viti, B; Ciboddo, G; Gerevini, S; Capra, R; Filippi, M;
Indirizzi:
San Raffaele Sci Inst, Dept Neurosci, Neuroimaging Res Unit, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 Res Unit, I-20132 Milan, Italy San Raffaele Sci Inst, Dept Med, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 Dept Med, I-20132 Milan, Italy San Raffaele Sci Inst, Dept Neuroradiol, I-20132 Milan, Italy San RaffaeleSci Inst Milan Italy I-20132 roradiol, I-20132 Milan, Italy Spedali Civili, Dept Neurol, I-25125 Brescia, Italy Spedali Civili Brescia Italy I-25125 Dept Neurol, I-25125 Brescia, Italy
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 1, volume: 247, anno: 2000,
pagine: 29 - 33
SICI:
0340-5354(200001)247:1<29:TCOFMF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENUATED INVERSION-RECOVERY; FAST SPIN-ECHO; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS LESIONS; NEURO-BEHCETS DISEASE; LUPUS-ERYTHEMATOSUS; PULSE SEQUENCES; VASCULITIS; LOAD; REPRODUCIBILITY;
Keywords:
magnetic resonance imaging; turbo spin echo; fast fluid attenuated inversion recovery; systemic autoimmune diseases; brain lesions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Filippi, M San Raffaele Sci Inst, Dept Neurosci, Neuroimaging Res Unit, Via Olgettina60, I-20132 Milan, Italy San Raffaele Sci Inst Via Olgettina 60 Milan Italy I-20132 aly
Citazione:
M. Rovaris et al., "The contribution of fast-FLAIR MRI for lesion detection in the brain of patients with systemic autoimmune diseases", J NEUROL, 247(1), 2000, pp. 29-33

Abstract

Fast fluid-attenuated inversion recovery (fFLAIR) is more sensitive that conventional or fast spin echo T2-weighted magnetic resonance imaging (MRI) for detecting lesions in the brain of patients with ischemic, inflammatory,or demyelinating diseases of the CNS. We investigated whether the use of fFLAIR also increases the sensitivity of brain MRI assessment in patients with systemic autoimmune disorders. Turbo spin echo (TSE) dual-echo and fFLAIR scans of the brain were obtained from patients affected by systemic lupuserythematosus (SLE) with (NSLE, n = 9) and without clinical CNS involvement (n = 15), Behcet disease (n = 5), Wegener granulomatosis (n = 9), and antiphospholipid antibody syndrome (n = 6). Brain hyperintense lesions were counted and classified according to their size and their location by two observers by consensual agreement. The total lesion volume was measured using asemiautomated technique for lesion segmentation on both TSE and fFLAIR scans. The imaging modalities showed brain hyperintense lesions in all 9 SLE patients with CNS involvement, 5 of 15 SLE patients without CNS involvement,5 of 9 patients with Wegener granulomatosis, I of 5 with Behcet disease, and 3 of 6 with antiphospholipid antibody syndrome. A total of 342 lesions were seen on both sequences; 88 were seen only on TSE and 54 only on fFLAIR scans. The average number of brain lesions per scan was higher on TSE than on fFLAIR, since significantly more discrete (P < 0.002) and small (P = 0.004) lesions were seen on TSE than on fFLAIR. The median total lesion volume, however, was similar on TSE and fFLAIR. Our study indicates that the use of fFLAIR does not improve the sensitivity of fast dual-echo MRI for detecting brain abnormalities in patients with systemic autoimmune disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 05:19:20