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Titolo:
Frontal lobe dysfunction in progressive supranuclear palsy: Evidence for oxidative stress and mitochondrial impairment
Autore:
Albers, DS; Augood, SJ; Park, LCH; Browne, SE; Martin, DM; Adamson, J; Hutton, M; Standaert, DG; Vonsattel, JPG; Gibson, GE; Beal, MF;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA Cornell Univ New York NY USA 10021 rol & Neurosci, New York, NY 10021 USA Cornell Univ, Coll Med, Burke Med Res Inst, White Plains, NY 10605 USA Cornell Univ White Plains NY USA 10605 s Inst, White Plains, NY 10605 USA Massachusetts Gen Hosp, Neurol Serv, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 rol Serv, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Neuropathol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ropathol, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 vard Univ, Sch Med, Boston, MA 02114 USA Mayo Clin Jacksonville, Jacksonville, FL 32224 USA Mayo Clin JacksonvilleJacksonville FL USA 32224 cksonville, FL 32224 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 2, volume: 74, anno: 2000,
pagine: 878 - 881
SICI:
0022-3042(200002)74:2<878:FLDIPS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-KETOGLUTARATE DEHYDROGENASE; POSITRON EMISSION TOMOGRAPHY; PROTEIN-TAU; NEUROFIBRILLARY TANGLES; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; COENZYME Q(10); HUMAN-BRAIN; DEMENTIA; HYPOMETABOLISM;
Keywords:
tauopathy; lipid peroxidation; mitochondrial dysfunction; malondialdehyde;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Albers, DS Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, Room A503,525 E 68thSt, New York, NY 10021 USA Cornell Univ Room A503,525 E 68th St New York NY USA 10021 USA
Citazione:
D.S. Albers et al., "Frontal lobe dysfunction in progressive supranuclear palsy: Evidence for oxidative stress and mitochondrial impairment", J NEUROCHEM, 74(2), 2000, pp. 878-881

Abstract

Recent data from our laboratory have shown a regionally specific increase in lipid peroxidation in postmortem progressive supranuclear palsy (PSP) brain. To extend this finding, we measured activities of mitochondrial enzymes as well as tissue malondialdehyde (MDA) levels in postmortem superior frontal cortex (Brodmann's area 9; SFC) from 14 pathologically confirmed casesof PSP and 13 age-matched control brains. Significant decreases (-39%) in alpha-ketoglutarate dehydrogenase complex/glutamate dehydrogenase ratio andsignificant increases (+36%) in tissue MDA levels were observed in the SFCin PSP; no differences in complex I or complex IV activities were detected. Together, these results suggest that mitochondrial dysfunction and lipid peroxidation may underlie the frontal metabolic and functional deficits observed in PSP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:20:50