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Titolo:
CNTF and its receptor subunits in human gliomas
Autore:
Weis, J; Schonrock, LM; Zuchner, SL; Lie, DC; Sure, U; Schul, C; Stogbauer, F; Ringelstein, EB; Halfter, H;
Indirizzi:
Univ Bern, Inst Pathol, Div Neuropathol, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 europathol, CH-3010 Bern, Switzerland RWTH Univ Hosp, Inst Neuropathol, Aachen, Germany RWTH Univ Hosp Aachen Germany v Hosp, Inst Neuropathol, Aachen, Germany RWTH Univ Hosp, Dept Neurosurg, Aachen, Germany RWTH Univ Hosp Aachen Germany niv Hosp, Dept Neurosurg, Aachen, Germany Univ Hosp, Dept Neurosurg, Munster, Germany Univ Hosp Munster GermanyUniv Hosp, Dept Neurosurg, Munster, Germany Univ Hosp, Dept Neurol, Munster, Germany Univ Hosp Munster GermanyUniv Hosp, Dept Neurol, Munster, Germany
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 3, volume: 44, anno: 1999,
pagine: 243 - 253
SICI:
0167-594X(1999)44:3<243:CAIRSI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CILIARY NEUROTROPHIC FACTOR; LEUKEMIA INHIBITORY FACTOR; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA EXPRESSION; PROGENITOR-CELL LINE; GROWTH-INHIBITION; SIGNAL TRANSDUCER; REACTIVE GLIOSIS; ALPHA COMPONENT; DEVELOPING RAT;
Keywords:
astrocytoma; glioblastoma; CNTF; CNTF receptor alpha; gp130; LIF receptor beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Weis, J Univ Bern, Inst Pathol, Div Neuropathol, Murtenstr 31, CH-3010 Bern, Switzerland Univ Bern Murtenstr 31 Bern Switzerland CH-3010 Bern, Switzerland
Citazione:
J. Weis et al., "CNTF and its receptor subunits in human gliomas", J NEURO-ONC, 44(3), 1999, pp. 243-253

Abstract

Ciliary neurotrophic factor (CNTF) promotes the survival of various neuronal cell populations. It is produced by astrocytes and influences the development and differentiation of glial cells. CNTF and related neuropoietic cytokines affect growth and differentiation of various neoplasms. Moreover, they induce the reactive transformation of astrocytes (gliosis) and influencegrowth and differentiation of neuroectodermal tumor cell lines in vitro. However, their role in gliomas is largely unknown. We studied the expressionof CNTF and its receptor subunits in human astrocytomas and glioblastomas. In more than 95% of the tumors, CNTF transcripts were found by RNAase protection assay; in more than 80% of the cases, tumor cells were CNTF immunoreactive. CNTF receptor alpha (CNTFR alpha), the specific component of the tripartite CNTF receptor system, was detectable by Northern blot analysis in 80% of the cases. In situ hybridization revealed CNTFR alpha mRNA in the cytoplasm of neoplastic cells. Transcripts of the remaining two components ofthe CNTF receptor system, gp130 and LIFR beta, were found by Northern blotting in 83% and 70% of the tumors, respectively. Simultaneous expression ofCNTF and all its receptor components was detected in approximately half ofthe tumors. These results indicate that CNTF and its receptor components are expressed by human glioma cells. The simultaneous expression of ligands and receptor subunits suggests that CNTF might act on human glioma cells via an auto- or paracrine mechanism.

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Documento generato il 28/01/21 alle ore 09:56:37