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Titolo:
[C-11]Methylation on a C-18 Sep-Pak cartridge: a convenient way to produce[N-methyl-C-11]choline
Autore:
Pascali, C; Bogni, A; Iwata, R; Cambie, M; Bombardieri, E;
Indirizzi:
Natl Canc Inst, Div Nucl Med, I-20133 Milan, Italy Natl Canc Inst Milan Italy I-20133 t, Div Nucl Med, I-20133 Milan, Italy Tohoku Univ, CYRIC, Aoba Ku, Sendai, Miyagi 9808578, Japan Tohoku Univ Sendai Miyagi Japan 9808578 Ku, Sendai, Miyagi 9808578, Japan
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 2, volume: 43, anno: 2000,
pagine: 195 - 203
SICI:
0362-4803(200002)43:2<195:[OACSC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PET; CHOLINE;
Keywords:
[(11)]C]choline; PET; solid supported methylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Bombardieri, E Natl Canc Inst, Div Nucl Med, V Venezian 1, I-20133 Milan, Italy Natl Canc Inst V Venezian 1 Milan Italy I-20133 lan, Italy
Citazione:
C. Pascali et al., "[C-11]Methylation on a C-18 Sep-Pak cartridge: a convenient way to produce[N-methyl-C-11]choline", J LABEL C R, 43(2), 2000, pp. 195-203

Abstract

[N-Methyl-C-11]choline has been simply and efficiently labelled at room temperature by solid supported [C-11]methylation of 2-dimethylaminoethanol ona commercial C-18 Sep-Pak Light cartridge. The labelled product was retained on a cation exchange resin (Sep-Pak Plus Accell Plus CM) and washed withethanol and water to remove any excess precursor. Then [N-methyl-C-11]choline was desorbed from the cartridge by elution with saline, passed through a 0.2 mu m sterile filter and collected in a sterile vial. Overall, the total synthesis time was 12 min from the end of bombardment (EOB). The radiochemical yield from [C-11]CO2, decay corrected (EOB) was 87% and the radiochemical purity was greater than 99%. Very conveniently, the automated apparatus employed is a very simple modification of the system routinely used for the synthesis of L-[S-methyl-C-11]methionine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:19:44