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Titolo:
Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar
Autore:
Lee, SH; Shin, MS; Kim, HS; Park, WS; Kim, SY; Jang, JJ; Rhim, KJ; Jang, J; Lee, HK; Park, JY; Oh, RR; Han, SY; Lee, JH; Lee, JY; Yoo, NJ;
Indirizzi:
Catholic Univ Korea, Coll Med, Dept Pathol, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 151, South Korea Seoul Natl Univ Seoul South Korea 151 ept Pathol, Seoul 151, South Korea Seoul Natl Univ, Coll Med, Canc Res Ctr, Seoul 151, South Korea Seoul NatlUniv Seoul South Korea 151 nc Res Ctr, Seoul 151, South Korea Korea Canc Ctr Hosp, Dept Dermatol, Seoul, South Korea Korea Canc Ctr Hosp Seoul South Korea Dept Dermatol, Seoul, South Korea
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 1, volume: 114, anno: 2000,
pagine: 122 - 126
SICI:
0022-202X(200001)114:1<122:SMOF(G>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; P53 GENE; APOPTOSIS; CD95; FAS/APO-1; POLYMORPHISMS; LEUKEMIA; ANTIGEN; TUMORS; MICE;
Keywords:
apoptosis; loss of heterozygosity; skin; squamous cell carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Yoo, NJ Catholic Univ Korea, Coll Med, Dept Pathol, 505 Banpo Dong,Socho Gu, Seoul137701, South Korea Catholic Univ Korea 505 Banpo Dong,Socho Gu Seoul South Korea 137701
Citazione:
S.H. Lee et al., "Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar", J INVES DER, 114(1), 2000, pp. 122-126

Abstract

Fas (Apo-1/CD95) is a cell-surface receptor involved in cell death signaling, and recent reports have suggested that defects within the Fas receptor pathway such as Fas mutation play an important part in the development and progression of human tumors. Burn scar-related squamous cell carcinoma of skin is a unique subtype of cutaneous squamous cell carcinoma, and tends to be more aggressive in nature than conventional squamous cell carcinoma. Themolecular mechanisms underlying the development and progression of burn scar-related squamous cell carcinoma, however, are not clear. In this study, we analyzed the entire coding region and all splice sites of the Fas gene for the detection of the somatic mutations in a series of 50 conventional squamous cell carcinomas and 21 burn scar-related squamous cell carcinomas bypolymerase chain reaction, single strand conformation polymorphism, and DNA sequencing. We detected mis-sense mutations in three of 21 burn scar-related squamous cell carcinomas (14.3%), whereas no mutation was detected in 50 conventional squamous cell carcinomas. Of the three Fas mutations detected in the burn scar-related squamous cell carcinomas, one was found in Fas ligand-binding domain, another one was identified in the death domain known to be involved in the transduction of an apoptotic signal, and the other one was found in the transmembrane domain. Our data show that some burn scar-related squamous cell carcinomas have Fas gene mutations in important regions for the apoptosis function and suggest that these mutations might be involved in the pathogenesis of burn scar-related squamous cell carcinomas. Inaddition, our results provide an important clue to understanding the difference between burn scar-related squamous cell carcinoma and conventional squamous cell carcinoma at the molecular level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:11:28