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Titolo:
c-Src mediates mitogenic signals and associates with cytoskeletal proteinsupon vascular endothelial growth factor stimulation in Kaposi's sarcoma cells
Autore:
Munshi, N; Groopman, JE; Gill, PS; Ganju, RK;
Indirizzi:
Harvard Univ, Beth Israel Deaconess Med Ctr, Div Expt Med & Hematol Oncol,Sch Med,Inst Med,Robert Mapplethorpe Lab, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 t Mapplethorpe Lab, Boston, MA 02115 USA Univ So Calif, Norris Canc Ctr, Div Hematol Oncol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 l Oncol, Los Angeles, CA 90033 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 164, anno: 2000,
pagine: 1169 - 1174
SICI:
0022-1767(20000201)164:3<1169:CMMSAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; TYROSINE KINASE; PERMEABILITY FACTOR; TAT PROTEIN; IMMUNODEFICIENCY-SYNDROME; TRANSDUCTION PATHWAYS; FLK-1/KDR RECEPTOR; COUPLED RECEPTOR; ONCOSTATIN-M; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Ganju, RK Harvard Univ, Beth Israel Deaconess Med Ctr, Div Expt Med & Hematol Oncol,Sch Med,Inst Med,Robert Mapplethorpe Lab, 4 Blackfan Circle, Boston, MA 02115 USA Harvard Univ 4 Blackfan Circle Boston MA USA 02115 MA 02115 USA
Citazione:
N. Munshi et al., "c-Src mediates mitogenic signals and associates with cytoskeletal proteinsupon vascular endothelial growth factor stimulation in Kaposi's sarcoma cells", J IMMUNOL, 164(3), 2000, pp. 1169-1174

Abstract

Vascular endothelial growth factor (VEGF) appears to be a critical cytokine modulating the growth and spread of Kaposi's sarcoma (KS), Furthermore, infection with the KS herpes virus results in up-regulation of VEGF and triggering of VEGF receptor activation. The molecular mechanisms regulating such cytokine-driven proliferation of KS cells are not well characterized. We investigated the role of Src-related tyrosine kinases in VEGF-mediated signaling in model KS 38 tumor cells. VEGF stimulation specifically activated c-Src kinase activity but not that of other related Src kinases such as Lyn,Fyn, or Hck in KS cells. Pyrazolopyrimidine, a selective inhibitor of Src family tyrosine kinases, significantly blocked the VEGF-induced growth of KS cells. Further studies using mutants of c-Src kinase revealed that Src mediates mitogen-activated protein kinase activation induced by VEGF, We alsoobserved that VEGF stimulation resulted in increased tyrosine phosphorylation of the focal adhesion components paxillin and p130(cas). Furthermore, VEGF induction enhanced the complex formation between Src kinase and paxillin. Src kinase appears to play an important functional role in VEGF-induced signaling in KS cells and may act to link pathways from the VEGF receptor to mitogen-activated protein kinase and cytoskeletal components, thereby effecting tumor proliferation and migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:37:40