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Titolo:
Cutting edge: A novel function for the SLAP-130/FYB adapter protein in beta(1) integrin signaling and T lymphocyte migration
Autore:
Hunter, AJ; Ottoson, N; Boerth, N; Koretzky, GA; Shimizu, Y;
Indirizzi:
Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Ctr Immunol,Canc Ctr, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 nc Ctr, Minneapolis, MN 55455 USA Univ Penn, Sch Med, Dept Pathol & Lab Med, Leonard & Madlyn Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Res Inst, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 164, anno: 2000,
pagine: 1143 - 1147
SICI:
0022-1767(20000201)164:3<1143:CEANFF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; MEDIATED TYROSINE PHOSPHORYLATION; CELL-MIGRATION; DEPENDENT ACTIVATION; MOLECULAR-CLONING; FYN; SLP-76; SUBSTRATE; COSTIMULATION; STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Hunter, AJ Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Ctr Immunol,Canc Ctr, Box 334 Mayo 6-266 BSBE,312 Church St SE, Minneapolis, MN 55455 USA Univ Minnesota Box 334 Mayo 6-266 BSBE,312 Church St SE Minneapolis MN USA 55455
Citazione:
A.J. Hunter et al., "Cutting edge: A novel function for the SLAP-130/FYB adapter protein in beta(1) integrin signaling and T lymphocyte migration", J IMMUNOL, 164(3), 2000, pp. 1143-1147

Abstract

The role of integrin-mediated signaling events in T cell function remains incompletely characterized. We report here that alpha(4)beta(1) integrin stimulation of H9 T cells and normal human T cell blasts results in rapid andtransient tyrosine phosphorylation of the adapter protein, SH2 domain-containing 76-kDa protein (SLP-76)-associated phosphoprotein of 130 kDa (SLAP-130)/FYB at levels comparable to those observed following TCR stimulation. Stimulation of T cells via the alpha(4)beta(1) integrin enhances the association of tyrosine phosphorylated SLAP-130/FYB with the SH2 domain of the srctyrosine kinase p59(fyn). Activation of normal T cells, but not H9 T cells, via alpha(4)beta(1) leads to tyrosine phosphorylation of SLP-76 as well as SLAP-130/FYB. Overexpression of SLAP-130/FYB in normal T cells enhances Tcell migration through fibronectin-coated filters in response to the chemokine stromal cell-derived factor (SDF)-1 alpha. These results identify SLAP-130/FYB as a new tyrosine phosphorylated substrate in beta(1) integrin signaling and suggest a novel function for SLAP-130/FYB in regulating T lymphocyte motility.

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Documento generato il 26/11/20 alle ore 10:47:26