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Titolo:
MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters
Autore:
Adjou, KT; Privat, N; Demart, S; Deslys, JP; Seman, M; Hauw, JJ; Dormont, D;
Indirizzi:
CEA, Serv Neurovirol, DSV DRM, CRSSA, F-92265 Fontenay Aux Roses, France CEA Fontenay Aux Roses France F-92265 F-92265 Fontenay Aux Roses, France Labs Mayoly Spindler, F-78401 Chatou, France Labs Mayoly Spindler ChatouFrance F-78401 ndler, F-78401 Chatou, France Hop La Pitie Salpetriere, Assoc Claude Bernard, Lab Escourolle, INSERM,U360, F-75651 Paris, France Hop La Pitie Salpetriere Paris France F-75651 360, F-75651 Paris, France Univ Paris 07, Inst Jacques Monod, Lab Immunodifferenciat, F-75251 Paris 05, France Univ Paris 07 Paris France 05 munodifferenciat, F-75251 Paris 05, France
Titolo Testata:
JOURNAL OF COMPARATIVE PATHOLOGY
fascicolo: 1, volume: 122, anno: 2000,
pagine: 3 - 8
SICI:
0021-9975(200001)122:1<3:MAABAD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYENE ANTIBIOTICS; PRION PROTEIN; MOUSE; INFECTIVITY; REPLICATION; TISSUE; AGENT; BSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Adjou, KT CEA, Serv Neurovirol, DSV DRM, CRSSA, BP 6,60-68 Ave Gen Leclerc, F-92265 Fontenay Aux Roses, France CEA BP 6,60-68 Ave Gen Leclerc Fontenay Aux Roses France F-92265
Citazione:
K.T. Adjou et al., "MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters", J COMP PATH, 122(1), 2000, pp. 3-8

Abstract

The histopathological response of scrapie-infected hamsters treated at thelate stage of the infection with an "anti-scrapie" drug, a polyene macrolide antibiotic, designated MS-8209, was evaluated in the brain. The results showed that (1) MS-8209 prolonged significantly the incubation lime of the experimental disease,:2) MS-8209 delayed the appearance of spongiosis and astrogliosis in the brain, (3) immunodetection of abnormal prion protein andglial fibrillary acidic protein was significantly reduced in the central nervous system.:In addition, this report indicates that polyene antibiotics markedly delay the development of the classical brain lesions that result from scrapie infection. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:45:05