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Titolo:
Effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: A retrospective survey
Autore:
Zimmet, SV; Strous, RD; Burgess, ES; Kohnstamm, S; Green, AI;
Indirizzi:
Massachusetts Mental Hlth Ctr, Commonwealth Res Ctr, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr Boston MA USA 02115 r, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Dept Psychiat, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 20, anno: 2000,
pagine: 94 - 98
SICI:
0271-0749(200002)20:1<94:EOCOSU>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENTAL-ILLNESS; DRUG-ABUSE; ALCOHOL; SMOKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Green, AI 74 Fenwood Rd, Boston, MA 02115 USA 74 Fenwood Rd Boston MA USA02115 wood Rd, Boston, MA 02115 USA
Citazione:
S.V. Zimmet et al., "Effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: A retrospective survey", J CL PSYCH, 20(1), 2000, pp. 94-98

Abstract

Substance use disorders, particularly those involving alcohol, marijuana, and cocaine, are highly prevalent among patients with schizophrenia and contribute markedly to its overall morbidity, Unfortunately, standard (typical) antipsychotic medications do not seem to reduce substance use in patientswith schizophrenia and may even increase it. Recently, however, a few anecdotal case reports and two previous small "N" surveys have found that clozapine, an atypical antipsychotic medication, seems to decrease substance usein patients treated with this drug for their psychoses. The authors reportdata from a retrospective survey of substance use in 58 patients treated with clozapine who had a history of comorbid schizophrenia (or schizoaffective disorder) and substance use disorder. Of these 58 patients, 43 were being treated with clozapine at the time of the survey; the remaining 15 patients had discontinued clozapine before the survey. The survey involved chart review and clinician interview to assess change in substance use and globalclinical symptoms while receiving treatment with clozapine. More than 85% of the patients who were active substance users at the time of initiation of treatment with clozapine decreased their substance use over the course ofclozapine administration. For patients who continued treatment with clozapine up to the present, the decrease in substance use was strongly correlated with a decrease in global clinical symptoms. Data from this retrospectivesurvey further support the previous observations that clozapine reduces substance use among patients with schizophrenic disorders. Moreover, the datasuggest the need for prospective controlled studies of the effects of clozapine on substance use in this population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:15:50