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Titolo:
Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats
Autore:
Larsson, E; Nanobashvili, A; Kokaia, Z; Lindvall, O;
Indirizzi:
Univ Lund Hosp, Wallenberg Neurosci Ctr, Sect Restorat Neurol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Restorat Neurol, S-22185 Lund, Sweden
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 11, volume: 19, anno: 1999,
pagine: 1220 - 1228
SICI:
0271-678X(199911)19:11<1220:EFNEOE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; FOCAL CEREBRAL-ISCHEMIA; MESSENGER-RNA; GROWTH-FACTOR; ANTEROGRADE TRANSPORT; CHOLINERGIC NEURONS; MOLECULAR-CLONING; TRK FAMILY; BDNF; EXPRESSION;
Keywords:
brain-derived neurotrophic factor; cerebral ischemia; rat; striatum; hippocampus; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Larsson, E Univ Lund Hosp, Wallenberg Neurosci Ctr, Sect Restorat Neurol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 urol, S-22185 Lund, Sweden
Citazione:
E. Larsson et al., "Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats", J CEREBR B, 19(11), 1999, pp. 1220-1228

Abstract

The levels of brain-derived neurotrophic factor (BDNF) vary between different forebrain areas and show region-specific changes after cerebral ischemia. The present study explores the possibility that the levels of endogenousBDNF determine the susceptibility to ischemic neuronal death. To block BDNF activity the authors used the TrkB-Fc fusion protein, which was infused intraventriculary in rats during 1 week before and 1 week after 5 or 30 minutes of global forebrain ischemia. Ischemic damage was quantified in the striatum and hippocampal formation after 1 week of reperfusion using immunocytochemistry and stereological procedures. After the 30-minute insult, there was a significantly lower number of surviving CA4 pyramidal neurons, neuropeptide Y-immunoreactive dentate hilar neurons, and choline acetyltransferase- and TrkA-positive, cholinergic striatal interneurons in the TrkB-Fc-infused rats as compared to controls, In contrast, the TrkB-Fc treatment did not influence survival of CA1 or CA3 pyramidal neurons or striatal projectionneurons. Also, after the mild ischemic insult (5 minutes), neuronal death in the CA1 region was similar in the TrkB-Fc-treated and control groups. These results indicate that endogenous BDNF can protect certain neuronal populations against ischemic damage. It is conceivable, though, that efficient neuroprotection after brain insults is dependent not only on this factor but on the concerted action of a large number of neurotrophic molecules.

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Documento generato il 03/12/20 alle ore 04:43:49