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Titolo:
Relationship between inward rectifier potassium current impairment and brain injury after cerebral ischemia/reperfusion
Autore:
Bastide, M; Bordet, R; Pu, Q; Robin, E; Puisieux, F; Dupuis, B;
Indirizzi:
CHU Lille, Pharmacol Lab, F-59037 Lille, France CHU Lille Lille France F-59037 lle, Pharmacol Lab, F-59037 Lille, France
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 12, volume: 19, anno: 1999,
pagine: 1309 - 1315
SICI:
0271-678X(199912)19:12<1309:RBIRPC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; HYPERTENSIVE RAT; CHANNEL FUNCTION; ISCHEMIA; ARTERIES; K+; ENDOTHELIUM; DILATION; PIGLETS; STROKE;
Keywords:
potassium inward rectifier current; patch clamp; rat middle cerebral artery; ischemia/reperfusion; brain infarct volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bastide, M Fac Med Lille, Pharmacol Lab, 1 Pl Verdun, F-59045 Lille, France Fac Med Lille 1 Pl Verdun Lille France F-59045 5 Lille, France
Citazione:
M. Bastide et al., "Relationship between inward rectifier potassium current impairment and brain injury after cerebral ischemia/reperfusion", J CEREBR B, 19(12), 1999, pp. 1309-1315

Abstract

Functional alterations of barium-sensitive potassium inward rectifier (K IR) current, which is involved in the vasodilation of middle cerebral arteries (MCA) in rat brain, have been described during brain ischemia/reperfusion (I/R). The authors investigate the effects of I/R on KIR current recordedin isolated myocytes from MCA of control rats and from contralateral and ipsilateral MCA of ischemic rats by the whole-cell patch-clamp technique, and the relationship between its alteration and the severity of brain injury. The vascular smooth muscle cells exhibited similar morphologic features inall conditions, and the KIR was present in the three groups of myocytes, exhibiting a characteristic inward rectification and a normal external potassium dependence The KIR density was significantly reduced in cell of MCA ipsilateral to occlusion with a maximum at -135 mV, whereas there was no difference between control and contralateral cells. This alteration in KIR density in occluded MCA was significantly correlated with severity of brain injury and brain edema. These results suggest that the alteration of KIR density in MCA myocytes after I/R and the consecutive impaired dilation of MCA may contribute to aggravation of the brain injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:50:55