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Titolo:
Quantification of delta-opioid receptors in human brain with N1 '-([C-11]methyl) naltrindole and positron emission tomography
Autore:
Smith, JS; Zubieta, JK; Price, JC; Flesher, JE; Madar, I; Lever, JR; Kinter, CM; Dannals, TF; Frost, JJ;
Indirizzi:
Johns Hopkins Med Inst, Div Nucl Med, Dept Radiol, Baltimore, MD USA JohnsHopkins Med Inst Baltimore MD USA , Dept Radiol, Baltimore, MD USA Johns Hopkins Med Inst, Dept Environm Hlth Sci, Div Radiat Hlth Sci, Baltimore, MD USA Johns Hopkins Med Inst Baltimore MD USA diat Hlth Sci, Baltimore, MD USA Johns Hopkins Med Inst, Dept Neurosci, Baltimore, MD USA Johns Hopkins MedInst Baltimore MD USA Dept Neurosci, Baltimore, MD USA
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 9, volume: 19, anno: 1999,
pagine: 956 - 966
SICI:
0271-678X(199909)19:9<956:QODRIH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 CARFENTANIL BINDING; TEMPORAL-LOBE EPILEPSY; TIME UPTAKE DATA; OPIATE RECEPTORS; RAT-BRAIN; GRAPHICAL EVALUATION; TRANSFER CONSTANTS; KINETIC-ANALYSIS; BLOOD-FLOW; INVIVO;
Keywords:
delta receptors; human brain; kinetic modeling; metabolites-N1 '-([C-11]methyl) naltrindole; naltrindole; opioid receptors; Patlak analysis; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Frost, JJ Johns Hopkins Univ, Sch Med, Div Nucl Med, Dept Radiol, Room B1-130,600 N Wolfe St, Baltimore, MD 21215 USA Johns Hopkins Univ Room B1-130,600 N Wolfe St Baltimore MD USA 21215
Citazione:
J.S. Smith et al., "Quantification of delta-opioid receptors in human brain with N1 '-([C-11]methyl) naltrindole and positron emission tomography", J CEREBR B, 19(9), 1999, pp. 956-966

Abstract

The regional binding of N1'-([C-11]methyl)naltrindole (MeNTI), a selectivedelta-opioid antagonist, was studied in healthy human subjects with positron emission tomography (PET). After the bolus intravenous administration ofhigh specific activity [C-11]MeNTI, PET was performed over 90 minutes. Arterial plasma samples were obtained during the scanning period and assayed for the presence of radiolabeled metabolites. The data were analyzed with various kinetic (two and three-compartment models, Patlak graphical analysis)and nonkinetic (apparent volume of distribution and activity at a late scanning time) approaches. This tracer showed irreversible binding characteristics during the scanning period used. The results of the analyses also werecompared with the density and distribution of delta-opioid receptors in the human brain in vitro. Additionally, computer simulations were performed to assess the effects of changes in receptor binding and tracer transport changes on the perceived binding parameters obtained with the models. A constrained three-compartment kinetic model was demonstrated to be superior to other quantification models for the description of MeNTI kinetics and quantification of delta receptor binding in the human brain with C-11-labeled MeNTI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:16:15