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Titolo:
Growth factors improve muscle healing in vivo
Autore:
Menetrey, J; Kasemkijwattana, C; Day, CS; Bosch, P; Vogt, M; Fu, FH; Moreland, MS; Huard, J;
Indirizzi:
Childrens Hosp Pittsburgh, Musculoskeletal Res Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15261 USA Childrens Hosp Pittsburgh Pittsburgh PA USA 15261 ittsburgh, PA 15261 USA Childrens Hosp Pittsburgh, Athlet Dept, Div Sports Med, Pittsburgh, PA 15261 USA Childrens Hosp Pittsburgh Pittsburgh PA USA 15261 ittsburgh, PA 15261 USA Univ Pittsburgh, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 tsburgh, Pittsburgh, PA 15261 USA
Titolo Testata:
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
fascicolo: 1, volume: 82B, anno: 2000,
pagine: 131 - 137
SICI:
0301-620X(200001)82B:1<131:GFIMHI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INJURED GASTROCNEMIUS-MUSCLE; AFFINITY NGF RECEPTOR; SKELETAL-MUSCLE; FACTOR-I; SATELLITE CELLS; REGENERATION; EXPRESSION; RAT; DIFFERENTIATION; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Huard, J Childrens Hosp Pittsburgh, Musculoskeletal Res Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15261 USA Childrens Hosp Pittsburgh Pittsburgh PA USA 15261 , PA 15261 USA
Citazione:
J. Menetrey et al., "Growth factors improve muscle healing in vivo", J BONE-BR V, 82B(1), 2000, pp. 131-137

Abstract

Injury to muscles is very common. We have previously observed that basic fibroblast growth factor (b-FGF), insulin growth factor type 1 (IGF-1) and nerve growth factor (NGF) are potent stimulators of the proliferation and fusion of myoblasts in vitro. We therefore injected these growth factors intomice with lacerations of the gastrocnemius muscle. The muscle regenerationwas evaluated at one week by histological staining and quantitative histology. Muscle healing was assessed histologically and the contractile properties were measured one month after injury. Our findings showed that h-FGF, IGF and to a less extent NGF enhanced muscle regeneration in vivo compared with control muscle. At one month, muscles treated with IGF-1 and b-FGF showed improved healing and significantly increased fast-twitch and tetanus strengths. Our results suggest that b-FGF and IGF-1 stimulated muscle healing and may have a considerable effect on the treatment of muscle injuries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:55:37