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Titolo:
Mitochondrial events in the life and death of animals cell: A brief overview
Autore:
Pedersen, PL;
Indirizzi:
Johns Hopkins Univ, Sch Med, Lab Cell Energet & Mol Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ol Med, Baltimore, MD 21205 USA
Titolo Testata:
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
fascicolo: 4, volume: 31, anno: 1999,
pagine: 291 - 304
SICI:
0145-479X(199908)31:4<291:MEITLA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C-OXIDASE; BOVINE HEART-MITOCHONDRIA; ATP SYNTHASE; RAT-LIVER; OXIDATIVE DAMAGE; DNA MUTATIONS; 2.8-ANGSTROM RESOLUTION; PERMEABILITY TRANSITION; DEGENERATIVE DISEASES; SUPEROXIDE-DISMUTASE;
Keywords:
cell death; aging; necrosis; apoptosis; mitochondria; oxidative phosphorylation; electron transport chain; ATP synthase; cytochrome c; mitochondrial DNA; reactive oxygen species (ROS);
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, PL Johns Hopkins Univ, Sch Med, Lab Cell Energet & Mol Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 more, MD 21205 USA
Citazione:
P.L. Pedersen, "Mitochondrial events in the life and death of animals cell: A brief overview", J BIOENER B, 31(4), 1999, pp. 291-304

Abstract

Traditionally, mitochondria have been viewed as the "powerhouse" of the cell, i.e., the site of the oxidative phosphorylation machinery involved in ATP production. Consequently, much of the research conducted on mitochondriaover the past 4 decades has focused on elucidating both those molecular events involved in ATP synthesis by oxidative phosphorylation and those involved in the biogenesis of the oxidative phosphorylation machinery. While monumental achievements have been made, and continue to be made, in the study of these remarkable but extremely complex processes essential for the life of most animal cells, it has been only in recent years that a large body ofbiological and biomedical scientists have come to recognize that mitochondria participate in other important processes. Two of these are cell death and aging which, not surprisingly, are related processes both involving, in part, the oxidative phosphorylation machinery. This new awareness has sparked a new and growing area of mitochondrial research, that has become of great interest to a wide variety of scientists ranging from those involved in elucidating the role of mitochondria in cell death and aging to those interested in either suppressing or facilitating these processes as it relates to identifying new therapies or drugs for human disease. It is the purpose of this brief introductory review to provide an overview of those mitochondrial events involved in the life and death of animal cells and to indicate how these-events might relate to the human aging process. Much more is known, much remains controversial, and even more remains to be learned as indicated in the excellent set of minireviews that follow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:55:31