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Titolo:
Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment
Autore:
Vujaskovic, Z; Poulson, JM; Gaskin, AA; Thrall, DE; Page, RL; Charles, HC; MacFall, JR; Brizel, DM; Meyer, RE; Prescott, DM; Samulski, TV; Dewhirst, MW;
Indirizzi:
Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 tr, Dept Radiat Oncol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Radiol, Durham, NC 27710 USA N Carolina State Univ, Coll Vet Med, Raleigh, NC USA N Carolina State Univ Raleigh NC USA Univ, Coll Vet Med, Raleigh, NC USA VCA Vet Referral Associates Inc, Gaithersburg, MD USA VCA Vet Referral Associates Inc Gaithersburg MD USA Gaithersburg, MD USA
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 1, volume: 46, anno: 2000,
pagine: 179 - 185
SICI:
0360-3016(20000101)46:1<179:TCIPPO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR OXYGENATION; RADIATION-THERAPY; PH; HYPERGLYCEMIA; COMBINATION; PERFUSION; IMPROVE; HYPOXIA;
Keywords:
tumors; hyperthermia blood how; pO(2); pH; thermal dose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Dewhirst, MW Duke Univ, Med Ctr, Dept Radiat Oncol, Box 3455 DUMC, Durham,NC 27710 USA Duke Univ Box 3455 DUMC Durham NC USA 27710 ham, NC 27710 USA
Citazione:
Z. Vujaskovic et al., "Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment", INT J RAD O, 46(1), 2000, pp. 179-185

Abstract

Purpose: The objectives of this study were to evaluate effects of hyperthermia on tumor oxygenation, extracellular pH (pHe), and blood flow in 13 dogs with spontaneous soft tissue sarcomas prior to and after local hyperthermia. Methods and Materials: Tumor pO(2) was measured using an Eppendorf polarographic device, pHe using interstitial electrodes, and blood flow using contrast-enhanced magnetic resonance imaging (MRI),Results: There was an overall improvement in tumor oxygenation observed asan increase in median pO(2) and decrease in hypoxic fraction (% of pO(2) measurements < 5 mmHg) at 24-h post hyperthermia. These changes were most pronounced when the median temperature (T-50) during hyperthermia treatment was less than 44 degrees C, Tumors with T-50 > 44 degrees C were characterized by a decrease in median pO(2) and an increase in hypoxic fraction. Similar thermal dose-related changes were observed in tumor perfusion. Perfusionwas significantly higher after hyperthermia, Increases in perfusion were most evident in tumors with T-50 < 44 degrees C, With T-50 > 44 degrees C, there was no change in perfusion after hyperthermia. On average, pHe values declined in all animals after hyperthermia, with the greatest reduction seen for larger T-50 values. Conclusion: This study suggests that hyperthermia has biphasic effects on tumor physiologic parameters. Lower temperatures tend to favor improved perfusion and oxygenation, whereas higher temperatures are more likely to cause vascular damage, thus leading to greater hypoxia, While it has long been recognized that such effects occur in rodent tumors, this is the first report to tie such changes to temperatures achieved during hyperthermia in the clinical setting. Furthermore, it suggests that the thermal threshold for vascular damage is higher in spontaneous tumors than in more rapidly growingrodent tumors. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:31:04