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Titolo:
Modulation of transforming growth factor beta 1 gene expression in the mammary gland by insulin-like growth factor I and octreotide
Autore:
Huynh, H; Beamer, W; Pollak, M; Chan, TWMG;
Indirizzi:
Natl Canc Ctr Singapore, Mol Endocrinol Lab, Div Cellular & Mol Res, Singapore 169610, Singapore Natl Canc Ctr Singapore Singapore Singapore 169610ore 169610, Singapore
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 2, volume: 16, anno: 2000,
pagine: 277 - 281
SICI:
1019-6439(200002)16:2<277:MOTGFB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER-CELLS; PURE ANTIESTROGEN ICI-182780; SOMATOSTATIN ANALOGS; SOMATOMEDIN RECEPTOR; IGF-I; TAMOXIFEN; INHIBITION; APOPTOSIS; BINDING; MICE;
Keywords:
TGF-beta 1; mammary gland; IGF-I; octreotide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Huynh, H Natl Canc Ctr Singapore, Mol Endocrinol Lab, Div Cellular & Mol Res, 11 Hosp Dr, Singapore 169610, Singapore Natl Canc Ctr Singapore 11 HospDr Singapore Singapore 169610 re
Citazione:
H. Huynh et al., "Modulation of transforming growth factor beta 1 gene expression in the mammary gland by insulin-like growth factor I and octreotide", INT J ONCOL, 16(2), 2000, pp. 277-281

Abstract

Transforming growth factor beta 1 (TGF-beta 1) has been shown to exhibit anti-proliferative activity for mammary gland epithelial cells and for humanbreast cancer cells. Insulin-like growth factor I (IGF-I), in contrast, isa well-characterized mitogenic and anti-apoptotic factor involved in mammary gland physiology. In order to examine the hypothesis that IGF-I suppresses TGF-beta 1 expression in the mammary gland, we studied the effect of various manipulations of the growth hormone - IGF-I axis on TGF-beta 1 mRNA abundance. Administration of IGF-I to intact animal suppressed TGF-beta 1 mRNA levels in a dose-dependent manner to similar to 20% of control levels. Administration of the somatostatin analogue octreotide in a manner previouslyshown to acutely suppress the growth hormone - IGF-I axis increased mammary gland TGF-beta 1 expression similar to 3-fold. Transgenic mice overexpressing growth hormone expressed TGF-beta 1 in the mammary gland at only similar to 12% of the level of control animals, while mice IGF-I deficient due to the 'lit' mutation expressed TGF-beta 1 at slightly higher levels than control animals. The large differences in TGF-beta 1 expression between control and GH-transgenic animals were correlated with major differences in architecture of the mammary gland, while the appearance of mammary glands of normal and 'lit' animals was similar. These data document a previously unrecognized relationship between TGF-beta 1 and IGF-I physiology in the mammary gland, and suggest a novel mechanism by which somatostatin analogues influence the proliferative behaviour of breast epithelial cells.

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Documento generato il 29/09/20 alle ore 00:25:17