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Titolo:
The CD44 variant isoforms CD44v6 and CD44v7 are expressed by distinct leukocyte subpopulations and exert non-overlapping functional activities
Autore:
Seiter, S; Schmidt, DS; Zoller, M;
Indirizzi:
German Canc Res Ctr, Dept Tumor Progress & Immune Def, D-69120 Heidelberg,Germany German Canc Res Ctr Heidelberg Germany D-69120 -69120 Heidelberg,Germany Univ Saarland, Dept Dermatol, D-66424 Hamburg, Germany Univ Saarland Hamburg Germany D-66424 Dermatol, D-66424 Hamburg, Germany Univ Karlsruhe, Dept Appl Genet, D-76049 Karlsruhe, Germany Univ Karlsruhe Karlsruhe Germany D-76049 net, D-76049 Karlsruhe, Germany
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 1, volume: 12, anno: 2000,
pagine: 37 - 49
SICI:
0953-8178(200001)12:1<37:TCVICA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; DELAYED-TYPE HYPERSENSITIVITY; LYMPHOCYTE HOMING RECEPTOR; MONOCLONAL-ANTIBODIES; HYALURONATE; RESPONSES; MOLECULE; ADHESION; PGP-1; MOUSE;
Keywords:
CD44 isoforms; co-stimulatory function; cytokines; delayed-type hypersensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Zoller, M German Canc Res Ctr, Dept Tumor Progress & Immune Def, Neuenheimer Feld 280, D-69120 Heidelberg, Germany German Canc Res Ctr Neuenheimer Feld 280 Heidelberg Germany D-69120
Citazione:
S. Seiter et al., "The CD44 variant isoforms CD44v6 and CD44v7 are expressed by distinct leukocyte subpopulations and exert non-overlapping functional activities", INT IMMUNOL, 12(1), 2000, pp. 37-49

Abstract

We have described recently that anti-CD44s, anti-cD44v6 and anti-CD44v7 interfere with delayed-type hypersensitivity (DTH) reactions. Yet, TNBS-induced colitis can be cured only by anti-CD44v7. To clarify the mechanisms underlying the divergent functional activities of CD44v6 and CD44v7 we exploredtheir contribution to lymphocyte activation in vivo and in vitro. CD44v6 and CD44v7 are distinctly expressed on subpopulations of activated lymphocytes. Expression of CD44v6 is mainly restricted to T cell blasts. CD44v7 has been detected on CD4(+) cells, B cells and monocytes. Mitogenic and antigenic stimulation of lymphocytes in vitro was impaired in the presence of anti-CD44v6 and anti-CD44v7. Accordingly, anti-CD44v6 and anti-CD44v7 mitigatedthe DTH reaction in 2,4-dlnitro-1-fluorobenzene-sensitized and challenged mice. However, the seemingly similar effects of CD44v6- and CD44v7-specificantibodies resulted from different activities. Anti-CD44v6 treatment led to a down-regulation of IL-2 and IFN-gamma production predominantly by CD8(+) cells. In anti-CD44v7-treated mice expression of IL-12 was decreased. Elevated levels of IL-10 accompanied this reduction. The latter resulted from an anti-CD44v7-mediated blockade of interactions between CD4+ cells and monocytes as well as an active triggering of B cells. Thus, anti-CD44v7 and anticD44v7 interfere with lymphocyte activation at very specific points. CD44v6 functions predominantly at the T cell level. CD44v7 influences production of proinflammatory cytokines by B cells as well as an interaction betweenCD4(+) cells and antigen-presenting cells. As CD44 isoforms do not differ in their intracytoplasmatic tail, the distinct activities must result from expression on different leukocyte subsets and interactions with distinct ligands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:58:52