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Titolo:
Effects of reproductive hormones on experimental vaginal candidiasis
Autore:
Fidel, PL; Cutright, J; Steele, C;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 2, volume: 68, anno: 2000,
pagine: 651 - 657
SICI:
0019-9567(200002)68:2<651:EORHOE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-SYSTEM; ALBICANS; MICE; PROGESTERONE; PATHOGENESIS; SUPPRESSION; INFECTIONS; SECRETIONS; ESTRADIOL; VAGINITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Fidel, PL Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, 1901 Perdido St, New Orleans, LA 70112 USA Louisiana State Univ 1901 Perdido St New Orleans LA USA 70112 SA
Citazione:
P.L. Fidel et al., "Effects of reproductive hormones on experimental vaginal candidiasis", INFEC IMMUN, 68(2), 2000, pp. 651-657

Abstract

Vulvovaginal candidiasis (VVC) is an opportunistic mucosal infection caused by Candida albicans that affects large numbers of otherwise healthy womenof childbearing age. Acute episodes of WC often occur during pregnancy andduring the luteal phase of the menstrual cycle, when levels of progesterone and estrogen are elevated. Although estrogen-dependent experimental rodent models of C. albicans vaginal infection are used for many applications, the role of reproductive hormones and/or their limits in the acquisition of vaginal candidiasis remain unclear. This study examined the effects of estrogen and progesterone on several aspects of an experimental infection together with relative cell-mediated immune responses. Results showed that whiledecreasing estrogen concentrations eventually influenced infection-inducedvaginal titers of C. albicans and rates of infection in inoculated animals, the experimental infection could not be achieved in mice treated with various concentrations of progesterone alone. Furthermore, progesterone had noeffect on (i) the induction and persistence of the infection in the presence of estrogen, (ii) delayed-type hypersensitivity in primary-infected mice, or (iii) the partial protection from a secondary vaginal infection under pseudoestrus conditions. Other results with estrogen showed that a persistent infection could be established with a,vide range of C. albicans inocula under supraphysiologic and near-physiologic (at estrus) concentrations of estrogen and that vaginal fungus titers or rates of infection were similar if pseudoestrus was initiated several days before or after inoculation. However, the pseudoestrus state had to be maintained for the infection to persist. Finally, estrogen was found to reduce the ability of vaginal epithelialcells to inhibit the growth of C. albicans. These results suggest that estrogen, but not progesterone, is an important factor in hormone-associated susceptibility to C. albicans vaginitis.

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Documento generato il 03/07/20 alle ore 22:44:46